Prestress-dependent propagation of forces to the nucleolus

Ning Wang, Shaohua Hu, James P. Butler

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We quantified displacements of nucleolar structures in cultured interphase cells in response to a localized physiologic oscillatory load via a magnetic bead. The computed size and shape deformations of nucelolar structures exhibited heterogeneous patterns. The peak displacements of the nucleolus decayed much slower in distance from the load than conventional homogeneous models predict. Increasing the pre-existing tensile stress (prestress) in the cytoskeleton (CSK) significantly increased the stress propagation efficiency to the nucleolus whereas decreasing the prestress significantly lowered the stress propagation efficiency to the nucleolus. These results demonstrate that the prestress in the CSK is crucial in mediating stress propagation to the nucleolus.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
Number of pages2
StatePublished - 2005
Externally publishedYes
Event2005 Summer Bioengineering Conference - Vail, CO, United States
Duration: Jun 22 2005Jun 26 2005


Other2005 Summer Bioengineering Conference
Country/TerritoryUnited States
CityVail, CO

ASJC Scopus subject areas

  • Engineering(all)


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