Preparation of Surfactant-Resistant Polymersomes with Ultrathick Membranes through RAFT Dispersion Polymerization

Ziyuan Song; Yinzhao Huang; Vikram Prasad; Ryan Baumgartner; Siyi Zhang; Keith Harris; Joshua S. Katz; Jianjun Cheng

doi:10.1021/acsami.6b05847

Preparation of Surfactant-Resistant Polymersomes with Ultrathick Membranes through RAFT Dispersion Polymerization

Ziyuan Song, Yinzhao Huang, Vikram Prasad, Ryan Baumgartner, Siyi Zhang, Keith Harris, Joshua S. Katz, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

Surfactant-resistant polymersomes have substantial potential to be used as delivery vehicles in industrial applications. Herein, we report the preparation of poly(ethylene oxide)-block-polystyrene copolymers with ultrahigh hydrophobic-block molecular weights through RAFT dispersion polymerization, which allows the polymerization-induced self-assembly into well-defined polymersomes with ultrathick membranes up to ∼47 nm. These ultrathick membranes significantly enhance the resistance against surfactant solubilization of the vesicles, improving the vesicles' potential for use in industrial encapsulations. Vesicle-encapsulated actives are well retained in the presence of up to 40 wt % of various anionic and nonionic surfactants, with less than 7% active leakage being observed after 30 days.

Original language	English (US)
Pages (from-to)	17033-17037
Number of pages	5
Journal	ACS Applied Materials and Interfaces
Volume	8
Issue number	27
DOIs	https://doi.org/10.1021/acsami.6b05847
State	Published - Jul 13 2016

Keywords

RAFT dispersion polymerization
anionic and nonionic surfactants
membrane thickness
polymersome
surfactant resistance

ASJC Scopus subject areas

Materials Science(all)

Online availability

10.1021/acsami.6b05847

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title = "Preparation of Surfactant-Resistant Polymersomes with Ultrathick Membranes through RAFT Dispersion Polymerization",

abstract = "Surfactant-resistant polymersomes have substantial potential to be used as delivery vehicles in industrial applications. Herein, we report the preparation of poly(ethylene oxide)-block-polystyrene copolymers with ultrahigh hydrophobic-block molecular weights through RAFT dispersion polymerization, which allows the polymerization-induced self-assembly into well-defined polymersomes with ultrathick membranes up to ∼47 nm. These ultrathick membranes significantly enhance the resistance against surfactant solubilization of the vesicles, improving the vesicles' potential for use in industrial encapsulations. Vesicle-encapsulated actives are well retained in the presence of up to 40 wt % of various anionic and nonionic surfactants, with less than 7% active leakage being observed after 30 days.",

keywords = "RAFT dispersion polymerization, anionic and nonionic surfactants, membrane thickness, polymersome, surfactant resistance",

author = "Ziyuan Song and Yinzhao Huang and Vikram Prasad and Ryan Baumgartner and Siyi Zhang and Keith Harris and Katz, {Joshua S.} and Jianjun Cheng",

note = "Funding Information: This work is supported by The Dow Chemical Company. All TEM and SEM imaging were carried out in part in the Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. Publisher Copyright: {\textcopyright} 2016 American Chemical Society. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

year = "2016",

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doi = "10.1021/acsami.6b05847",

language = "English (US)",

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AU - Song, Ziyuan

AU - Huang, Yinzhao

AU - Prasad, Vikram

AU - Baumgartner, Ryan

AU - Zhang, Siyi

AU - Harris, Keith

AU - Katz, Joshua S.

AU - Cheng, Jianjun

N1 - Funding Information: This work is supported by The Dow Chemical Company. All TEM and SEM imaging were carried out in part in the Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. Publisher Copyright: © 2016 American Chemical Society. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.

PY - 2016/7/13

Y1 - 2016/7/13

N2 - Surfactant-resistant polymersomes have substantial potential to be used as delivery vehicles in industrial applications. Herein, we report the preparation of poly(ethylene oxide)-block-polystyrene copolymers with ultrahigh hydrophobic-block molecular weights through RAFT dispersion polymerization, which allows the polymerization-induced self-assembly into well-defined polymersomes with ultrathick membranes up to ∼47 nm. These ultrathick membranes significantly enhance the resistance against surfactant solubilization of the vesicles, improving the vesicles' potential for use in industrial encapsulations. Vesicle-encapsulated actives are well retained in the presence of up to 40 wt % of various anionic and nonionic surfactants, with less than 7% active leakage being observed after 30 days.

AB - Surfactant-resistant polymersomes have substantial potential to be used as delivery vehicles in industrial applications. Herein, we report the preparation of poly(ethylene oxide)-block-polystyrene copolymers with ultrahigh hydrophobic-block molecular weights through RAFT dispersion polymerization, which allows the polymerization-induced self-assembly into well-defined polymersomes with ultrathick membranes up to ∼47 nm. These ultrathick membranes significantly enhance the resistance against surfactant solubilization of the vesicles, improving the vesicles' potential for use in industrial encapsulations. Vesicle-encapsulated actives are well retained in the presence of up to 40 wt % of various anionic and nonionic surfactants, with less than 7% active leakage being observed after 30 days.

KW - RAFT dispersion polymerization

KW - anionic and nonionic surfactants

KW - membrane thickness

KW - polymersome

KW - surfactant resistance

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Preparation of Surfactant-Resistant Polymersomes with Ultrathick Membranes through RAFT Dispersion Polymerization

Abstract

Keywords

ASJC Scopus subject areas

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