Preparation of Structurally Diverse Compounds from the Natural Product Lycorine

Sarah Z. Tasker; Amanda E. Cowfer; Paul J. Hergenrother

doi:10.1021/acs.orglett.8b02562

Preparation of Structurally Diverse Compounds from the Natural Product Lycorine

Sarah Z. Tasker, Amanda E. Cowfer, Paul J. Hergenrother

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of a 52-member compound collection from the natural product lycorine is reported, highlighted by divergent cross-coupling and substitution strategies and an unusual ring rearrangement induced by reaction with aryne intermediates.

Original language	English (US)
Pages (from-to)	5894-5898
Number of pages	5
Journal	Organic Letters
Volume	20
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.8b02562
State	Published - Sep 21 2018

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.8b02562

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title = "Preparation of Structurally Diverse Compounds from the Natural Product Lycorine",

abstract = "The synthesis of a 52-member compound collection from the natural product lycorine is reported, highlighted by divergent cross-coupling and substitution strategies and an unusual ring rearrangement induced by reaction with aryne intermediates.",

author = "Tasker, {Sarah Z.} and Cowfer, {Amanda E.} and Hergenrother, {Paul J.}",

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doi = "10.1021/acs.orglett.8b02562",

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Preparation of Structurally Diverse Compounds from the Natural Product Lycorine

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