Preparation of Structurally Diverse Compounds from the Natural Product Lycorine

Sarah Z. Tasker, Amanda E. Cowfer, Paul Hergenrother

Research output: Contribution to journalArticle

Abstract

The synthesis of a 52-member compound collection from the natural product lycorine is reported, highlighted by divergent cross-coupling and substitution strategies and an unusual ring rearrangement induced by reaction with aryne intermediates.

Original languageEnglish (US)
Pages (from-to)5894-5898
Number of pages5
JournalOrganic Letters
Volume20
Issue number18
DOIs
StatePublished - Sep 21 2018

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cross coupling
Biological Products
Substitution reactions
substitutes
preparation
rings
synthesis
products
lycorine

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Preparation of Structurally Diverse Compounds from the Natural Product Lycorine. / Tasker, Sarah Z.; Cowfer, Amanda E.; Hergenrother, Paul.

In: Organic Letters, Vol. 20, No. 18, 21.09.2018, p. 5894-5898.

Research output: Contribution to journalArticle

Tasker, Sarah Z. ; Cowfer, Amanda E. ; Hergenrother, Paul. / Preparation of Structurally Diverse Compounds from the Natural Product Lycorine. In: Organic Letters. 2018 ; Vol. 20, No. 18. pp. 5894-5898.
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