Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous Pictet-Spengler cyclization

Richard R. Cesati; John A. Katzenellenbogen

doi:10.1021/ol006533u

Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous Pictet-Spengler cyclization

Richard R. Cesati, John A. Katzenellenbogen

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(matrix presented) A vinylogous Pictet-Spengler cyclization has been carried out using activated aldehydes, ketones, and alkynes to prepare a variety of substituted hexahydrobenzo[f]isoquinolines. A unique set of conditions was utilized to effect efficient cyclization with acid-sensitive electrophiles.

Original language	English (US)
Pages (from-to)	3635-3638
Number of pages	4
Journal	Organic Letters
Volume	2
Issue number	23
DOIs	https://doi.org/10.1021/ol006533u
State	Published - Nov 16 2000

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol006533u

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abstract = "(matrix presented) A vinylogous Pictet-Spengler cyclization has been carried out using activated aldehydes, ketones, and alkynes to prepare a variety of substituted hexahydrobenzo[f]isoquinolines. A unique set of conditions was utilized to effect efficient cyclization with acid-sensitive electrophiles.",

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Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous Pictet-Spengler cyclization

Abstract

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