Preparation of biocompatible nanocapsules with temperature-responsive and bioreducible properties

Zhong Kai Wang, Di Wang, Hua Wang, Jun Jie Yan, Ye Zi You, Zhi Gang Wang

Research output: Contribution to journalArticlepeer-review


Stimuli-responsive biocompatible nanocarriers are very promising for controlled drug release. Here, we report redox- and temperature-responsive biocompatible nanocapsules prepared by growing a temperature-responsive biocompatible shell from 3-(trimethoxysilyl)propyl methacrylate-modified silica nanoparticles (SiO2-MPS) via precipitation polymerization, cross-linking the shell with bioreducible chemical linkages, and subsequently removing the silica core by hydrofluoric acid etching. The produced nanocapsules are redox- and temperature-responsive. TEM, FT-IR, TGA, and XPS were used to characterize the nanocapsules. Dynamic light scattering (DLS) was performed to demonstrate the bioreducible and temperature-responsive properties of the nanocapsules. The lower critical solution temperature (LCST) of the nanocapsules can be tuned precisely. Fluorescein isothiocyanate (FITC) was encapsulated into the nanocapsules and used as a model drug molecule to demonstrate the controlled release behavior under external stimuli.

Original languageEnglish (US)
Pages (from-to)15950-15956
Number of pages7
JournalJournal of Materials Chemistry
Issue number40
StatePublished - Oct 28 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • Materials Chemistry


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