Abstract
A two-step conversion of 2-chloro-7-amido-1,8-naphthyridine to 2,7-diamino-1,8-naphthyridine is described. The process, which involves a nucleophilic aromatic substitution reaction with 4-methoxybenzylamine and subsequent deprotection, can be carried out on a large scale.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1435-1436 |
| Number of pages | 2 |
| Journal | Synlett |
| Issue number | 9 |
| DOIs | |
| State | Published - Jun 1 2005 |
Keywords
- Amine protecting group
- Heterocycles
- Hydrogen bond
- Nucleophilic aromatic substitution
- Supramolecular systems
ASJC Scopus subject areas
- Organic Chemistry
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