TY - JOUR
T1 - Prenatal exposure to traffic and ambient air pollution and infant weight and adiposity
T2 - The Healthy Start study
AU - Starling, Anne P.
AU - Moore, Brianna F.
AU - Thomas, Deborah S.K.
AU - Peel, Jennifer L.
AU - Zhang, Weiming
AU - Adgate, John L.
AU - Magzamen, Sheryl
AU - Martenies, Sheena E.
AU - Allshouse, William B.
AU - Dabelea, Dana
N1 - Funding Information:
This work was supported by grants from the National Institute of Environmental Health Sciences , National Institutes of Health , United States ( R00ES025817 ), the National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , United States ( R01DK076648 ), and the Office of the Director , National Institutes of Health , United States ( UH3OD023248 ). Funders had no involvement in the data collection, analysis, or interpretation of results, and were not involved in the writing of the article or the decision to submit the article for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Appendix A
Funding Information:
This work was supported by grants from the National Institute of Environmental Health Sciences, National Institutes of Health, United States (R00ES025817), the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States (R01DK076648), and the Office of the Director, National Institutes of Health, United States (UH3OD023248). Funders had no involvement in the data collection, analysis, or interpretation of results, and were not involved in the writing of the article or the decision to submit the article for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/3
Y1 - 2020/3
N2 - Background: Prenatal exposures to ambient air pollution and traffic have been associated with adverse birth outcomes, and may also lead to an increased risk of obesity. Obesity risk may be reflected in changes in body composition in infancy. Objective: To estimate associations between prenatal ambient air pollution and traffic exposure, and infant weight and adiposity in a Colorado-based prospective cohort study. Methods: Participants were 1125 mother-infant pairs with term births. Birth weight was recorded from medical records and body composition measures (fat mass, fat-free mass, and adiposity [percent fat mass]) were evaluated via air displacement plethysmography at birth (n = 951) and at ~5 months (n = 574). Maternal residential address was used to calculate distance to nearest roadway, traffic density, and ambient concentrations of fine particulate matter (PM2.5) and ozone (O3) via inverse-distance weighted interpolation of stationary monitoring data, averaged by trimester and throughout pregnancy. Adjusted linear regression models estimated associations between exposures and infant weight and body composition. Results: Participants were urban residents and diverse in race/ethnicity and socioeconomic status. Average ambient air pollutant concentrations were generally low; the median, interquartile range (IQR), and range of third trimester concentrations were 7.3 μg/m3 (IQR: 1.3, range: 3.3–12.7) for PM2.5 and 46.3 ppb (IQR: 18.4, range: 21.7–63.2) for 8-h maximum O3. Overall there were few associations between traffic and air pollution exposures and infant outcomes. Third trimester O3 was associated with greater adiposity at follow-up (2.2% per IQR, 95% CI 0.1, 4.3), and with greater rates of change in fat mass (1.8 g/day, 95% CI 0.5, 3.2) and adiposity (2.1%/100 days, 95% CI 0.4, 3.7) from birth to follow-up. Conclusions: We found limited evidence of an association between prenatal traffic and ambient air pollution exposure and infant body composition. Suggestive associations between prenatal ozone exposure and early postnatal changes in body composition merit further investigation.
AB - Background: Prenatal exposures to ambient air pollution and traffic have been associated with adverse birth outcomes, and may also lead to an increased risk of obesity. Obesity risk may be reflected in changes in body composition in infancy. Objective: To estimate associations between prenatal ambient air pollution and traffic exposure, and infant weight and adiposity in a Colorado-based prospective cohort study. Methods: Participants were 1125 mother-infant pairs with term births. Birth weight was recorded from medical records and body composition measures (fat mass, fat-free mass, and adiposity [percent fat mass]) were evaluated via air displacement plethysmography at birth (n = 951) and at ~5 months (n = 574). Maternal residential address was used to calculate distance to nearest roadway, traffic density, and ambient concentrations of fine particulate matter (PM2.5) and ozone (O3) via inverse-distance weighted interpolation of stationary monitoring data, averaged by trimester and throughout pregnancy. Adjusted linear regression models estimated associations between exposures and infant weight and body composition. Results: Participants were urban residents and diverse in race/ethnicity and socioeconomic status. Average ambient air pollutant concentrations were generally low; the median, interquartile range (IQR), and range of third trimester concentrations were 7.3 μg/m3 (IQR: 1.3, range: 3.3–12.7) for PM2.5 and 46.3 ppb (IQR: 18.4, range: 21.7–63.2) for 8-h maximum O3. Overall there were few associations between traffic and air pollution exposures and infant outcomes. Third trimester O3 was associated with greater adiposity at follow-up (2.2% per IQR, 95% CI 0.1, 4.3), and with greater rates of change in fat mass (1.8 g/day, 95% CI 0.5, 3.2) and adiposity (2.1%/100 days, 95% CI 0.4, 3.7) from birth to follow-up. Conclusions: We found limited evidence of an association between prenatal traffic and ambient air pollution exposure and infant body composition. Suggestive associations between prenatal ozone exposure and early postnatal changes in body composition merit further investigation.
KW - Adiposity
KW - Air pollution
KW - Infant
KW - Pregnancy
KW - Traffic
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U2 - 10.1016/j.envres.2020.109130
DO - 10.1016/j.envres.2020.109130
M3 - Article
C2 - 32069764
AN - SCOPUS:85077742672
SN - 0013-9351
VL - 182
JO - Environmental Research
JF - Environmental Research
M1 - 109130
ER -