Abstract
This study tested the hypothesis that prenatal DEHP exposure affects female reproduction. To test this hypothesis, pregnant female CD-1 mice were orally dosed daily with tocopherol-stripped corn oil (vehicle control) or DEHP (20. μg/kg/day-750. mg/kg/day) from gestation day 11-birth. Pups were counted, weighed, and sexed at birth, ovaries were subjected to evaluations of follicle numbers on postnatal days (PNDs) 8 and 21, and fertility was evaluated at 3-9 months. The results indicate that prenatal DEHP exposure increased male-to-female ratio compared to controls. Prenatal DEHP exposure also increased preantral follicle numbers at PND 21 compared to controls. Further, 22.2% of the 20. μg/kg/day treated animals took longer than 5 days to get pregnant at 3 months and 28.6% of the 750. mg/kg/day treated animals lost some of their pups at 6 months. Thus, prenatal DEHP exposure alters F1 sex ratio, increases preantral follicle numbers, and causes some breeding abnormalities.
Original language | English (US) |
---|---|
Pages (from-to) | 23-32 |
Number of pages | 10 |
Journal | Reproductive Toxicology |
Volume | 53 |
DOIs | |
State | Published - Jun 1 2015 |
Keywords
- DEHP
- Estrous cyclicity
- Female reproduction
- Ovary
- Phthalate
- Sex ratio
ASJC Scopus subject areas
- Toxicology