Preliminary Findings of a Previously Unrecognized Porcine Primary Immunodeficiency Disorder

A. G.Cino Ozuna, R. R.R. Rowland, J. C. Nietfeld, M. A. Kerrigan, J. C.M. Dekkers, C. R. Wyatt

Research output: Contribution to journalArticlepeer-review


Weaned pigs from a line bred for increased feed efficiency were enrolled in a study of the role of host genes in the response to infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Four of the pigs were euthanatized early in the study due to weight loss with illness and poor body condition; 2 pigs before PRRSV infection and the other 2 pigs approximately 2 weeks after virus inoculation. The 2 inoculated pigs failed to produce PRRSV-specific antibodies. Gross findings included pneumonia, absence of a detectable thymus, and small secondary lymphoid tissues. Histologically, lymph nodes, spleen, tonsils, and Peyer's patches were sparsely cellular with decreased to absent T and B lymphocytes.

Original languageEnglish (US)
Pages (from-to)144-146
Number of pages3
JournalVeterinary pathology
Issue number1
StatePublished - Jan 2013
Externally publishedYes


  • immunohistochemistry
  • lymphoid tissues
  • pig diseases
  • primary immunodeficiency

ASJC Scopus subject areas

  • General Veterinary


Dive into the research topics of 'Preliminary Findings of a Previously Unrecognized Porcine Primary Immunodeficiency Disorder'. Together they form a unique fingerprint.

Cite this