Preliminary Findings of a Previously Unrecognized Porcine Primary Immunodeficiency Disorder

A. G.Cino Ozuna, R. R.R. Rowland, J. C. Nietfeld, M. A. Kerrigan, J. C.M. Dekkers, C. R. Wyatt

Research output: Contribution to journalArticlepeer-review

Abstract

Weaned pigs from a line bred for increased feed efficiency were enrolled in a study of the role of host genes in the response to infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Four of the pigs were euthanatized early in the study due to weight loss with illness and poor body condition; 2 pigs before PRRSV infection and the other 2 pigs approximately 2 weeks after virus inoculation. The 2 inoculated pigs failed to produce PRRSV-specific antibodies. Gross findings included pneumonia, absence of a detectable thymus, and small secondary lymphoid tissues. Histologically, lymph nodes, spleen, tonsils, and Peyer's patches were sparsely cellular with decreased to absent T and B lymphocytes.

Original languageEnglish (US)
Pages (from-to)144-146
Number of pages3
JournalVeterinary pathology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • immunohistochemistry
  • lymphoid tissues
  • pig diseases
  • primary immunodeficiency

ASJC Scopus subject areas

  • veterinary(all)

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