@article{8dbd67fca1144780aec5149314e4a2cb,
title = "Preliminary Findings of a Previously Unrecognized Porcine Primary Immunodeficiency Disorder",
abstract = "Weaned pigs from a line bred for increased feed efficiency were enrolled in a study of the role of host genes in the response to infection with Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Four of the pigs were euthanatized early in the study due to weight loss with illness and poor body condition; 2 pigs before PRRSV infection and the other 2 pigs approximately 2 weeks after virus inoculation. The 2 inoculated pigs failed to produce PRRSV-specific antibodies. Gross findings included pneumonia, absence of a detectable thymus, and small secondary lymphoid tissues. Histologically, lymph nodes, spleen, tonsils, and Peyer's patches were sparsely cellular with decreased to absent T and B lymphocytes.",
keywords = "immunohistochemistry, lymphoid tissues, pig diseases, primary immunodeficiency",
author = "Ozuna, {A. G.Cino} and Rowland, {R. R.R.} and Nietfeld, {J. C.} and Kerrigan, {M. A.} and Dekkers, {J. C.M.} and Wyatt, {C. R.}",
note = "Funding Information: The authors thank Dr. Amanda Beck (KSU) for in-house review of the manuscript for accuracy of the pathology descriptions. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The feed efficiency lines of pigs were developed with funds from the Iowa Agriculture and Home Economics Experiment Station, Ames, Iowa (project no. 3600) and from the ISU Center for Integrated Animal Genomics, and supported by Hatch Act. The PRRSV infection trial was part of Agriculture and Food Research Initiative Competitive Grant no. 2011-68004-30336 from the USDA National Institute of Food and Agriculture. ",
year = "2013",
month = jan,
doi = "10.1177/0300985812457790",
language = "English (US)",
volume = "50",
pages = "144--146",
journal = "Pathologia veterinaria",
issn = "0300-9858",
publisher = "SAGE Publishing",
number = "1",
}