@inbook{42884536ca81433a917fdfd76ac9787c,
title = "Predicting ICU Admissions for Hospitalized COVID-19 Patients with a Factor Graph-based Model",
abstract = "This paper presents a factor graph-based model that takes comorbidities and clinical measurements as inputs and predicts intensive care unit (ICU) admissions 3 days and 7 days in advance for hospitalized COVID-19 patients. We applied the proposed model on a COVID-19 cohort from a large medical center in Chicago (with records from March 2020 to August 2021). We used the first occurrence of the Delta variant in the U.S., February 2021, as the threshold to divide the dataset into pre-Delta data (533 patients) and post-Delta data (56 patients). Our model demonstrated 0.82 AUC on the pre-Delta data and 0.87 AUC on the post-Delta data in 7-day predictions. Our contribution is a model that (i) explains relationships between different clinical features and provides interpretations for ICU admissions, (ii) outperforms existing methods for 7-day predictions, and (iii) maintains more robustness than existing models in predictions under the influence of the Delta variant. The proposed model could be used as a predictive tool in clinical practice to help clinicians in decision-making by predicting which patients will need ICU support in the future.",
keywords = "COVID-19 prognosis, Comorbidities, Factor graph, Predictive biomarkers, Probabilistic graphical model",
author = "Yurui Cao and Phuong Cao and Haotian Chen and Kochendorfer, {Karl M.} and Trotter, {Andrew B.} and Galanter, {William L.} and Arnold, {Paul M.} and Iyer, {Ravishankar K}",
note = "Funding Information: Acknowledgements This work was partly supported by the Center for Computational Biotechnology and Genomic Medicine, Carle Foundation Hospital, and the Jump ARCHES endowment fund. We thank Yufu Zhang, Jorge Rodriguez Fernandez, and Jai Nebhrajani for providing and interpreting the data. We also thank our colleagues in the DEPEND group, particularly Krishnakant Saboo, Chang Hu, Anirudh Choudhary, Mosbah Aouad, Yixin Chen, Kathleen Atchley, and Jenny Applequist for their valuable feedback. The project was also supported by the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through Grant Award Number UL1TR002003. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2023",
doi = "10.1007/978-3-031-14771-5_17",
language = "English (US)",
series = "Studies in Computational Intelligence",
publisher = "Springer",
pages = "245--256",
booktitle = "Studies in Computational Intelligence",
address = "Germany",
}