Preclinical animal behavioral models of hyperacusis and loudness recruitment

Kelly E. Radziwon, Senthilvelan Manohar, Benjamin Auerbach, Xiaopeng Liu, Guang Di Chen, Richard Salvi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hyperacusis is a loudness intolerance disorder in which everyday sounds are perceived as intolerably loud, annoying, fearful, or even painful. While hyperacusis is often considered exclusively as a hearing problem, it is associated with a broad spectrum of auditory (tinnitus), vestibular, and other neurological disorders such as autism, Williams syndrome, fibromyalgia, migraine, and a host of other sensory hypersensitivity disorders. The underlying mechanisms and biological basis of hyperacusis in its different manifestations are poorly understood largely due to the lack of valid behavioral models. In this review, we discuss recent advances in the development of behavioral models that have been used to measure various forms of hyperacusis and the genetic models and experimental conditions that have been employed to induce hyperacusis in animals.

Original languageEnglish (US)
Title of host publicationNew Therapies to Prevent or Cure Auditory Disorders
PublisherSpringer International Publishing
Pages135-157
Number of pages23
ISBN (Electronic)9783030404130
ISBN (Print)9783030404123
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • Hyperacusis
  • Loudness perception
  • Loudness recruitment
  • Operant conditioning
  • Reaction time
  • Sound avoidance

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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