TY - JOUR
T1 - Precise modulation of embryonic development through optogenetics
AU - Fan, Huaxun
AU - Barnes, Collin
AU - Hwang, Hyojeong
AU - Zhang, Kai
AU - Yang, Jing
N1 - The research reported in this publication was supported by the School of Molecular and Cellular Biology at UIUC, the National Institute of General Medical Sciences of the National Institutes of Health (R01GM132438 and R35GM131810), and the National Institute of Mental Health (R01MH124827), Scialog®, Research Corporation for Science Advancement (RCSA), the Frederick Gardner Cottrell Foundation, and the Paul G. Allen Frontiers Group (Award #27937).
PY - 2022/12
Y1 - 2022/12
N2 - The past decade has witnessed enormous progress in optogenetics, which uses photo-sensitive proteins to control signal transduction in live cells and animals. The ever-increasing amount of optogenetic tools, however, could overwhelm the selection of appropriate optogenetic strategies. In this work, we summarize recent progress in this emerging field and highlight the application of opsin-free optogenetics in studying embryonic development, focusing on new insights gained into optical induction of morphogenesis, cell polarity, cell fate determination, tissue differentiation, neuronal regeneration, synaptic plasticity, and removal of cells during development.
AB - The past decade has witnessed enormous progress in optogenetics, which uses photo-sensitive proteins to control signal transduction in live cells and animals. The ever-increasing amount of optogenetic tools, however, could overwhelm the selection of appropriate optogenetic strategies. In this work, we summarize recent progress in this emerging field and highlight the application of opsin-free optogenetics in studying embryonic development, focusing on new insights gained into optical induction of morphogenesis, cell polarity, cell fate determination, tissue differentiation, neuronal regeneration, synaptic plasticity, and removal of cells during development.
KW - embryonic development
KW - optogenetic actuators
KW - protein–protein interaction
KW - signal transduction
KW - spatiotemporal control
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U2 - 10.1002/dvg.23505
DO - 10.1002/dvg.23505
M3 - Review article
C2 - 36478118
AN - SCOPUS:85144046786
SN - 1526-954X
VL - 60
JO - Genesis (United States)
JF - Genesis (United States)
IS - 10-12
M1 - e23505
ER -