The A·T and G·C base-pairs have been investigated experimentally and computationally to examine whether they contain any special stability relative to other base pairs. An empirically based relationship between overall complex stability (-ΔG°) and various possible component interactions is developed to probe the question in a large set of experimentally determined base-pairs and their analogs. Unexpected stability is observed in the A·T pair, and its origin is examined computationally. The results and their possible relationship to prebiotic chemistry are described.
ASJC Scopus subject areas
- Chemical Engineering(all)