Prebiotic selection of the AT base-pair? A physical organic approach to understanding AT base-pair stability indicates special stability (1,2)

Jordan R. Quinn, Steven C. Zimmerman, Janet E. Del Bene, Isaiah Shavitt

Research output: Contribution to journalArticle

Abstract

The A·T and G·C base-pairs have been investigated experimentally and computationally to examine whether they contain any special stability relative to other base pairs. An empirically based relationship between overall complex stability (-ΔG°) and various possible component interactions is developed to probe the question in a large set of experimentally determined base-pairs and their analogs. Unexpected stability is observed in the A·T pair, and its origin is examined computationally. The results and their possible relationship to prebiotic chemistry are described.

Original languageEnglish (US)
Pages (from-to)95-107
Number of pages13
JournalACS Symposium Series
Volume1025
DOIs
StatePublished - Dec 20 2009

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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