Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold

Yugang Bai, Hang Xing, Gretchen A. Vincil, Jennifer Lee, Essence J. Henderson, Yi Lu, N. Gabriel Lemcoff, Steven C. Zimmerman

Research output: Contribution to journalArticle

Abstract

A new approach to prepare functional organic nanoparticles (ONPs) from linear polymers is described. The nanoparticles are obtained by ring-opening metathesis polymerisation (ROMP) of functionalised norbornene dicarboximides, side-chain amidation with tri-O-allyl-TRIS, and ring-closing metathesis (RCM). The synthesis is quite flexible and mild, allowing preparation of organic- and aqueous-soluble particles with narrow molecular weight (MW) distributions that are tunable, ranging from MW ≈ 10 to >100 kD with diameters between ca. 5 and 50 nm. The use of functional monomer(s) and/or chain-transfer agents (CTAs) leads to the fully controlled synthesis of nanoparticles containing single or multiple reactive functional groups. This non-toxic ONP scaffold can be readily used as a protective carrier for a broad range of groups using the appropriate monomers, such as a fluorescein-functionalised monomer that affords fluorescent ONPs with significantly enhanced photostability.

Original languageEnglish (US)
Pages (from-to)2862-2868
Number of pages7
JournalChemical Science
Volume5
Issue number7
DOIs
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Chemistry(all)

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