PP2A: B56E is required for Wnt/β-catenin signaling during embryonic development

Jing Yang, Jinling Wu, Change Tan, Peter S. Klein

Research output: Contribution to journalReview articlepeer-review


The Wnt/β-catenin pathway plays important roles during embryonic development and growth control. The B56 regulatory subunit of protein phosphatase 2A (PP2A) has been implicated as a regulator of this pathway. However, this has not been investigated by loss-of-function analyses. Here we report loss-of-function analysis of PP2A:B56E during early Xenopus embryogenesis. We provide direct evidence that PP2A:B56E is required for Wnt/β-catenin signaling upstream of Dishevelled and downstream of the Wnt ligand. We show that maternal PP2A:B56E function is required for dorsal development, and PP2A:B56E function is required later for the expression of the Wnt target gene engrailed, for subsequent midbrain-hindbrain boundary formation, and for closure of the neural tube. These data demonstrate a positive role for PP2A:B56E in the Wnt pathway.

Original languageEnglish (US)
Pages (from-to)5569-5578
Number of pages10
Issue number23
StatePublished - Dec 2003
Externally publishedYes


  • B56
  • Embryo
  • Protein phosphatase 2A
  • Wnt/β-catenin
  • Xenopus

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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