Power Doppler imaging of acute renal transplant rejection

Manrita K. Sidhu, Sangeeta Gambhir, R. Brooke Jeffrey, F. Graham Sommer, King C.P. Li, Nancy R. Krieger, Edward J. Alfrey, John D. Scandling

Research output: Contribution to journalArticlepeer-review


Purpose. We evaluated the usefulness of power Doppler imaging (PDI) in diagnosing acute renal-transplant rejection. Methods. Twenty-eight patients underwent 33 renal-transplant biopsies for suspected acute rejection. Patterns of renal parenchymal vascularity revealed by PDI in patients with abnormal biopsy results were compared with patterns in a group who had normal biopsy results. PDI examinations were reviewed retrospectively by 2 independent radiologists who had no knowledge of the biopsy results. A PDI diagnosis of acute rejection required marked vascular pruning in both the cortex and medulla. PDI results then were compared with transplant-biopsy results. Results. The sensitivity and specificity of PDI for diagnosing acute renal-transplant rejection were 40% and 100%, respectively. None of the patients with negative biopsy results had PDI abnormalities. The negative predictive value of PDI was 33%, and the positive predictive value was 100%. Conclusions. In our study, an abnormal sonogram was highly predictive of acute transplant rejection. However, a normal sonogram did not exclude the possibility of rejection.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalJournal of Clinical Ultrasound
Issue number4
StatePublished - May 1999
Externally publishedYes


  • Doppler ultrasonography
  • Kidney
  • Transplantation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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