Potent anticancer activity via dual compound activation

Paul J Hergenrother; Rachel C Botham; Timothy M Fan; Mark John Gilbert; Michael Kevin Handley; Theodore M. Tarasow

Potent anticancer activity via dual compound activation

Paul J Hergenrother (Inventor), Rachel C Botham (Inventor), Timothy M Fan (Inventor), Mark John Gilbert (Inventor), Michael Kevin Handley (Inventor), Theodore M. Tarasow (Inventor)

Research output: Patent

Abstract

The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

Original language	English (US)
U.S. patent number	9592229
State	Published - Mar 14 2017

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title = "Potent anticancer activity via dual compound activation",

abstract = "The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.",

author = "Hergenrother, {Paul J} and Botham, {Rachel C} and Fan, {Timothy M} and Gilbert, {Mark John} and Handley, {Michael Kevin} and Tarasow, {Theodore M.}",

note = "GOVERNMENT SUPPORT This invention was made with government support under Grant Nos. R01-CA120439 and CA120439-52 awarded by the National Institutes of Health. The government has certain rights in the invention.; 9592229",

year = "2017",

month = mar,

day = "14",

language = "English (US)",

type = "Patent",

}

TY - PAT

T1 - Potent anticancer activity via dual compound activation

AU - Hergenrother, Paul J

AU - Botham, Rachel C

AU - Fan, Timothy M

AU - Gilbert, Mark John

AU - Handley, Michael Kevin

AU - Tarasow, Theodore M.

N1 - GOVERNMENT SUPPORT This invention was made with government support under Grant Nos. R01-CA120439 and CA120439-52 awarded by the National Institutes of Health. The government has certain rights in the invention.

PY - 2017/3/14

Y1 - 2017/3/14

N2 - The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

AB - The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

M3 - Patent

M1 - 9592229

ER -

Potent anticancer activity via dual compound activation

Abstract

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