Posttranslational modifications of NF-κB: Another layer of regulation for NF-κB signaling pathway

Bo Huang, Xiao Dong Yang, Acacia Lamb, Lin Feng Chen

Research output: Contribution to journalReview article

Abstract

The eukaryotic transcription factor NF-κB regulates a wide range of host genes that control the inflammatory and immune responses, programmed cell death, cell proliferation and differentiation. The activation of NF-κB is tightly controlled both in the cytoplasm and in the nucleus. While the upstream cytoplasmic regulatory events for the activation of NF-κB are well studied, much less is known about the nuclear regulation of NF-κB. Emerging evidence suggests that NF-κB undergoes a variety of posttranslational modifications, and that these modifications play a key role in determining the duration and strength of NF-κB nuclear activity as well as its transcriptional output. Here we summarize the recent advances in our understanding of the posttranslational modifications of NF-κB, the interplay between the various modifications, and the physiological relevance of these modifications.

Original languageEnglish (US)
Pages (from-to)1282-1290
Number of pages9
JournalCellular Signalling
Volume22
Issue number9
DOIs
StatePublished - Sep 2010

Keywords

  • Cancer
  • Inflammatory response
  • NF-κB
  • Posttranslational modifications
  • Transcriptional activation

ASJC Scopus subject areas

  • Cell Biology

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