@article{bc85901609fe44f8bc1cf74aa01b7853,
title = "Post-transcriptional gene regulation by mRNA modifications",
abstract = "The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N 6 -methyladenosine (m 6 A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation. N 6 -adenosine methylation directs mRNAs to distinct fates by grouping them for differential processing, translation and decay in processes such as cell differentiation, embryonic development and stress responses. Other mRNA modifications, including N 1 -methyladenosine (m 1 A), 5-methylcytosine (m 5 C) and pseudouridine, together with m 6 A form the epitranscriptome and collectively code a new layer of information that controls protein synthesis.",
author = "Zhao, \{Boxuan Simen\} and Roundtree, \{Ian A.\} and Chuan He",
note = "The authors apologize to colleagues whose work was not cited owing to space limitations. This research was supported by grants from the US National Institutes of Health (HG008688 and GM071440 to C.H.). C.H. is an investigator of the Howard Hughes Medical Institute (HHMI). B.S.Z. is an HHMI International Student Research Fellow. I.A.R. is supported by a National Research Service Award F30GM117646 from the National Institute of General Medical Sciences of the National Institutes of Health. The Mass Spectrometry Facility of the University of Chicago is funded by the National Science Foundation (CHE\textbackslash{}u20111048528). This research was supported by grants from the US National Institutes of Health (HG008688 and GM071440 to C.H.). C.H. is an investigator of the Howard Hughes Medical Institute (HHMI). B.S.Z. is an HHMI International Student Research Fellow. I.A.R. is supported by a National Research Service Award F30GM117646 from the National Institute of General Medical Sciences of the National Institutes of Health. The Mass Spectrometry Facility of the University of Chicago is funded by the National Science Foundation (CHE-1048528).",
year = "2016",
month = dec,
day = "19",
doi = "10.1038/nrm.2016.132",
language = "English (US)",
volume = "18",
pages = "31--42",
journal = "Nature Reviews Molecular Cell Biology",
issn = "1471-0072",
publisher = "Nature Research",
number = "1",
}