Possible clinical outcome measures for clinical trials in patients with multiple sclerosis

Myla D. Goldman, Robert W. Motl, Richard A. Rudick

Research output: Contribution to journalReview articlepeer-review


Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease with both clinical and pathological heterogeneity. The complexity of the MS population has offered challenges to the measurement of MS disease progression in therapeutic trials. The current standard clinical outcome measures are relapse rate, Expanded Disability Severity Scale (EDSS), and the MS Functional Composite (MSFC). These measures each have strengths and some weakness. Two additional measures, the six-minute walk and accelerometry, show promise in augmenting current measures. MS therapeutics is a quickly advancing field which requires sensitive clinical outcome measures that can detect small changes in disability that reliably reflect long-term changes in sustained disease progression in a complex population. A single clinical outcome measure of sustained disease progression may remain elusive. Rather, an integration of current and new outcome measures may be most appropriate and utilization of different measures depending on the MS population and stage of the disease may be preferred.

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalTherapeutic Advances in Neurological Disorders
Issue number4
StatePublished - Jul 2010


  • EDSS
  • MSFC
  • accelerometry
  • multiple sclerosis
  • outcome measures
  • six-minute walk

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology


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