Positive chronotropic effect caused by transthoracic ultrasound in heart of rats

Olivia C. Coiado; Rahul S. Yerrabelli; Anton P. Christensen; Marcin Wozniak; Alex Lucas; William D. O'Brien

doi:10.1121/10.0005764

Positive chronotropic effect caused by transthoracic ultrasound in heart of rats

Olivia C. Coiado, Rahul S. Yerrabelli, Anton P. Christensen, Marcin Wozniak, Alex Lucas, William D. O'Brien

Research output: Contribution to journal › Article › peer-review

Abstract

Pulsed ultrasound can produce chronotropic and inotropic effects on the heart with potential therapeutic applications. Fourteen 3-month-old female rats were exposed transthoracically to 3.5-MHz 2.0-MPa peak rarefactional pressure amplitude ultrasonic pulses of increasing 5-s duration pulse repetition frequency (PRF) sequences. An increase in the heart rate was observed following each PRF sequence: an ∼50% increase after the 4-5-6 Hz sequence, an ∼57% increase after the 5-6-7 Hz sequence, and an ∼48% increase after the 6-7-8 Hz sequence. Other cardiac parameters showed a normal or indicated a compensatory decrease at 3 and 15 min post-ultrasound compared to control.

Original language	English (US)
Article number	082001
Journal	JASA Express Letters
Volume	1
Issue number	8
DOIs	https://doi.org/10.1121/10.0005764
State	Published - Aug 1 2021

ASJC Scopus subject areas

Acoustics and Ultrasonics
Music
Arts and Humanities (miscellaneous)

Online availability

10.1121/10.0005764

Library availability

Discover UIUC Full Text

Cite this

@article{ee40a934e49846dcbac702fd6961715e,

title = "Positive chronotropic effect caused by transthoracic ultrasound in heart of rats",

abstract = "Pulsed ultrasound can produce chronotropic and inotropic effects on the heart with potential therapeutic applications. Fourteen 3-month-old female rats were exposed transthoracically to 3.5-MHz 2.0-MPa peak rarefactional pressure amplitude ultrasonic pulses of increasing 5-s duration pulse repetition frequency (PRF) sequences. An increase in the heart rate was observed following each PRF sequence: an ∼50% increase after the 4-5-6 Hz sequence, an ∼57% increase after the 5-6-7 Hz sequence, and an ∼48% increase after the 6-7-8 Hz sequence. Other cardiac parameters showed a normal or indicated a compensatory decrease at 3 and 15 min post-ultrasound compared to control.",

author = "Coiado, {Olivia C.} and Yerrabelli, {Rahul S.} and Christensen, {Anton P.} and Marcin Wozniak and Alex Lucas and O'Brien, {William D.}",

note = "Publisher Copyright: {\textcopyright} 2021 U.S. Government.",

year = "2021",

month = aug,

day = "1",

doi = "10.1121/10.0005764",

language = "English (US)",

volume = "1",

journal = "JASA Express Letters",

issn = "2691-1191",

publisher = "American Institute of Physics",

number = "8",

}

TY - JOUR

T1 - Positive chronotropic effect caused by transthoracic ultrasound in heart of rats

AU - Coiado, Olivia C.

AU - Yerrabelli, Rahul S.

AU - Christensen, Anton P.

AU - Wozniak, Marcin

AU - Lucas, Alex

AU - O'Brien, William D.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Pulsed ultrasound can produce chronotropic and inotropic effects on the heart with potential therapeutic applications. Fourteen 3-month-old female rats were exposed transthoracically to 3.5-MHz 2.0-MPa peak rarefactional pressure amplitude ultrasonic pulses of increasing 5-s duration pulse repetition frequency (PRF) sequences. An increase in the heart rate was observed following each PRF sequence: an ∼50% increase after the 4-5-6 Hz sequence, an ∼57% increase after the 5-6-7 Hz sequence, and an ∼48% increase after the 6-7-8 Hz sequence. Other cardiac parameters showed a normal or indicated a compensatory decrease at 3 and 15 min post-ultrasound compared to control.

AB - Pulsed ultrasound can produce chronotropic and inotropic effects on the heart with potential therapeutic applications. Fourteen 3-month-old female rats were exposed transthoracically to 3.5-MHz 2.0-MPa peak rarefactional pressure amplitude ultrasonic pulses of increasing 5-s duration pulse repetition frequency (PRF) sequences. An increase in the heart rate was observed following each PRF sequence: an ∼50% increase after the 4-5-6 Hz sequence, an ∼57% increase after the 5-6-7 Hz sequence, and an ∼48% increase after the 6-7-8 Hz sequence. Other cardiac parameters showed a normal or indicated a compensatory decrease at 3 and 15 min post-ultrasound compared to control.

UR - http://www.scopus.com/inward/record.url?scp=85177496007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85177496007&partnerID=8YFLogxK

U2 - 10.1121/10.0005764

DO - 10.1121/10.0005764

M3 - Article

AN - SCOPUS:85177496007

SN - 2691-1191

VL - 1

JO - JASA Express Letters

JF - JASA Express Letters

IS - 8

M1 - 082001

ER -

Positive chronotropic effect caused by transthoracic ultrasound in heart of rats

Abstract

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this