Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer

Freddy T. Nguyen, Adam M. Zysk, Jan G. Kotynek, Frank J. Bellafiore, Kendrith M. Rowland, Patricia A. Johnson, J. Eric Chaney, Stephen A. Boppart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Breast cancer continues to be one of the most widely diagnosed forms of cancer amongst women and the second leading type of cancer deaths amongst women. The recurrence rate of breast cancer is highly dependent on several factors including the complete removal of the primary tumor and the presence of cancer cells in involved lymph nodes. The metastatic spread and staging of breast cancer is also evaluated through the nodal assessment of the regional lymphatic system. A portable real-time spectral domain optical coherence tomography system is being presented as a clinical diagnostic tool in the intraoperative delineation of tumor margins as well as for real time lymph node assessment. The system employs a super luminescent diode centered at 1310 nm with a bandwidth of 92 nm. Using a spectral domain detection system, the data is acquired at a rate of 5 KHz / axial scan. The sample arm is a galvanometer scanning telecentric probe with an objective lens (f = 60 mm, confocal parameter = 1.5 mm) yielding an axial resolution of 8.3 μm and a transverse resolution of 35.0 μm. Images of tumor margins are acquired in the operating room ex vivo on freshly excised human tissue specimen. This data shows the potential of the use of OCT in defining the structural tumor margins in breast cancer. Images taken from ex-vivo samples on the bench system clearly delineate the differences between clusters of tumor cells and nearby adipose cells. In addition, the data shows the potential for OCT as a diagnostic tool in the staging of cancer metastasis through locoregional lymph node assessment.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems V
DOIs
StatePublished - Apr 30 2007
EventAdvanced Biomedical and Clinical Diagnostic Systems V - San Jose, CA, United States
Duration: Jan 21 2007Jan 27 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6430
ISSN (Print)1605-7422

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems V
CountryUnited States
CitySan Jose, CA
Period1/21/071/27/07

Fingerprint

Optical tomography
Tumors
Imaging techniques
Cells
Galvanometers
Operating rooms
Lenses
Diodes
Tissue
Scanning
Bandwidth

Keywords

  • Biomedical optics
  • Breast cancer
  • Clinical imaging
  • Image guided surgery
  • Lymph node
  • Metastasis
  • Optical coherence tomography

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Nguyen, F. T., Zysk, A. M., Kotynek, J. G., Bellafiore, F. J., Rowland, K. M., Johnson, P. A., ... Boppart, S. A. (2007). Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer. In Advanced Biomedical and Clinical Diagnostic Systems V [64300H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6430). https://doi.org/10.1117/12.701128

Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer. / Nguyen, Freddy T.; Zysk, Adam M.; Kotynek, Jan G.; Bellafiore, Frank J.; Rowland, Kendrith M.; Johnson, Patricia A.; Eric Chaney, J.; Boppart, Stephen A.

Advanced Biomedical and Clinical Diagnostic Systems V. 2007. 64300H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6430).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nguyen, FT, Zysk, AM, Kotynek, JG, Bellafiore, FJ, Rowland, KM, Johnson, PA, Eric Chaney, J & Boppart, SA 2007, Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer. in Advanced Biomedical and Clinical Diagnostic Systems V., 64300H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6430, Advanced Biomedical and Clinical Diagnostic Systems V, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.701128
Nguyen FT, Zysk AM, Kotynek JG, Bellafiore FJ, Rowland KM, Johnson PA et al. Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer. In Advanced Biomedical and Clinical Diagnostic Systems V. 2007. 64300H. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.701128
Nguyen, Freddy T. ; Zysk, Adam M. ; Kotynek, Jan G. ; Bellafiore, Frank J. ; Rowland, Kendrith M. ; Johnson, Patricia A. ; Eric Chaney, J. ; Boppart, Stephen A. / Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer. Advanced Biomedical and Clinical Diagnostic Systems V. 2007. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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