TY - JOUR
T1 - Porphyric insecticides. 1. Concept and phenomenology
AU - Rebeiz, Constantin A.
AU - Juvik, John A.
AU - Rebeiz, Carole C.
N1 - Funding Information:
’ This work was supported by Research Grant DMB 85-07217, by the John P. Trebellas Photobiotechnology Research Endowment to C. A. Rebeiz and by funds from the University of Illinois and the Illinois Agricultural Experiment Station to C. A. Rebeiz and J. A. Juvik. We thank Professors Robert Metcalf and Marcos Kogan for their constructive input while writing this manuscript and Professor Loren Bode for the droplet size measurements. ? Abbreviations used: DPY, 2,2’-dipyridyl: ALA, 6-aminolevulinic acid; DV, divinyl; Proto, DV protoporphyrin IX; MV, monovinyl; Chl. chlorophyll; Mg-Proto, DV Mg-protoporphyrin IX.
PY - 1988/1
Y1 - 1988/1
N2 - The concept and phenomenology of a new approach to the design of insecticides is described. The novel insecticides consist of modulators of the porphyrin-heme biosynthetic pathway, which, when used singly or in combination with δ-aminolevulinic acid, induce the massive accumulation of protoporphyrin IX in the treated insect. The uncontrolled protoporphyrin biosynthesis causes death of the treated insect in darkness and in light. In light, death appears to be photodynamic in nature. It is also shown that photodynamic damage can be induced by treating the insect with exogenous protoporphyrin or Mg-protoporphyrin. We propose the term "porphyric insecticides" to designate such insecticides. It is argued that the appeal of porphyric insecticides may reside (a) in the potential to design a large number of totally biodegradable formulations that can act as selective photodynamic insecticides and herbicides and (b) in the anticipated difficulty for insects to develop resistance toward such insecticides.
AB - The concept and phenomenology of a new approach to the design of insecticides is described. The novel insecticides consist of modulators of the porphyrin-heme biosynthetic pathway, which, when used singly or in combination with δ-aminolevulinic acid, induce the massive accumulation of protoporphyrin IX in the treated insect. The uncontrolled protoporphyrin biosynthesis causes death of the treated insect in darkness and in light. In light, death appears to be photodynamic in nature. It is also shown that photodynamic damage can be induced by treating the insect with exogenous protoporphyrin or Mg-protoporphyrin. We propose the term "porphyric insecticides" to designate such insecticides. It is argued that the appeal of porphyric insecticides may reside (a) in the potential to design a large number of totally biodegradable formulations that can act as selective photodynamic insecticides and herbicides and (b) in the anticipated difficulty for insects to develop resistance toward such insecticides.
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U2 - 10.1016/0048-3575(88)90055-7
DO - 10.1016/0048-3575(88)90055-7
M3 - Article
AN - SCOPUS:0023855250
SN - 0048-3575
VL - 30
SP - 11
EP - 27
JO - Pesticide Biochemistry and Physiology
JF - Pesticide Biochemistry and Physiology
IS - 1
ER -