Porous photonic crystal external cavity laser biosensor for drug screening

Qinglan Huang; Jessie Peh; Paul J. Hergenrother; Brian T. Cunningham

doi:10.1109/ICSENS.2016.7808619

Porous photonic crystal external cavity laser biosensor for drug screening

Qinglan Huang, Jessie Peh, Paul J. Hergenrother, Brian T. Cunningham

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report a photonic crystal (PC) biosensor that incorporates a porous TiO₂ film to boost sensitivity by enlarged surface area and enhanced interaction with the resonant electromagnetic fields. In the context of sensing small molecule interactions with proteins, the porous PC achieves 3.7x larger resonant wavelength shifts than an equivalent nonporous structure. Utilizing the porous PC as the wavelength selective element in an external cavity laser, the system provides narrow resonant linewidth via stimulated emission, and therefore establishes sub-picometer accuracy, representing a record high figure of merit for label free optical biosensors.

Original language	English (US)
Title of host publication	IEEE Sensors, SENSORS 2016 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479982875
DOIs	https://doi.org/10.1109/ICSENS.2016.7808619
State	Published - Jan 5 2016
Event	15th IEEE Sensors Conference, SENSORS 2016 - Orlando, United States Duration: Oct 30 2016 → Nov 2 2016

Publication series

Name	Proceedings of IEEE Sensors
Volume	0
ISSN (Print)	1930-0395
ISSN (Electronic)	2168-9229

Other

Other	15th IEEE Sensors Conference, SENSORS 2016
Country/Territory	United States
City	Orlando
Period	10/30/16 → 11/2/16

Keywords

Photonic crystal
external cavity laser
small molecule detection

ASJC Scopus subject areas

Electrical and Electronic Engineering

Online availability

10.1109/ICSENS.2016.7808619

Library availability

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Porous photonic crystal external cavity laser biosensor for drug screening. / Huang, Qinglan; Peh, Jessie; Hergenrother, Paul J. et al.
IEEE Sensors, SENSORS 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. 7808619 (Proceedings of IEEE Sensors; Vol. 0).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Huang, Q, Peh, J, Hergenrother, PJ & Cunningham, BT 2016, Porous photonic crystal external cavity laser biosensor for drug screening. in IEEE Sensors, SENSORS 2016 - Proceedings., 7808619, Proceedings of IEEE Sensors, vol. 0, Institute of Electrical and Electronics Engineers Inc., 15th IEEE Sensors Conference, SENSORS 2016, Orlando, United States, 10/30/16. https://doi.org/10.1109/ICSENS.2016.7808619

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abstract = "We report a photonic crystal (PC) biosensor that incorporates a porous TiO2 film to boost sensitivity by enlarged surface area and enhanced interaction with the resonant electromagnetic fields. In the context of sensing small molecule interactions with proteins, the porous PC achieves 3.7x larger resonant wavelength shifts than an equivalent nonporous structure. Utilizing the porous PC as the wavelength selective element in an external cavity laser, the system provides narrow resonant linewidth via stimulated emission, and therefore establishes sub-picometer accuracy, representing a record high figure of merit for label free optical biosensors.",

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N2 - We report a photonic crystal (PC) biosensor that incorporates a porous TiO2 film to boost sensitivity by enlarged surface area and enhanced interaction with the resonant electromagnetic fields. In the context of sensing small molecule interactions with proteins, the porous PC achieves 3.7x larger resonant wavelength shifts than an equivalent nonporous structure. Utilizing the porous PC as the wavelength selective element in an external cavity laser, the system provides narrow resonant linewidth via stimulated emission, and therefore establishes sub-picometer accuracy, representing a record high figure of merit for label free optical biosensors.

AB - We report a photonic crystal (PC) biosensor that incorporates a porous TiO2 film to boost sensitivity by enlarged surface area and enhanced interaction with the resonant electromagnetic fields. In the context of sensing small molecule interactions with proteins, the porous PC achieves 3.7x larger resonant wavelength shifts than an equivalent nonporous structure. Utilizing the porous PC as the wavelength selective element in an external cavity laser, the system provides narrow resonant linewidth via stimulated emission, and therefore establishes sub-picometer accuracy, representing a record high figure of merit for label free optical biosensors.

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Porous photonic crystal external cavity laser biosensor for drug screening

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