Abstract

We report the design, fabrication, and testing of a photonic crystal (PC) biosensor structure that incorporates a porous high refractive index TiO2 dielectric film that enables immobilization of capture proteins within an enhanced surface-area volume that spatially overlaps with the regions of resonant electromagnetic fields where biomolecular binding can produce the greatest shifts in photonic crystal resonant wavelength. Despite the nanoscale porosity of the sensor structure, the PC slab exhibits narrowband and high efficiency resonant reflection, enabling the structure to serve as a wavelength-tunable element of an external cavity laser. In the context of sensing small molecule interactions with much larger immobilized proteins, we demonstrate that the porous structure provides 3.7× larger biosensor signals than an equivalent nonporous structure, while the external cavity laser (ECL) detection method provides capability for sensing picometer-scale shifts in the PC resonant wavelength caused by small molecule binding. The porous ECL achieves a record high figure of merit for label-free optical biosensors.

Original languageEnglish (US)
Article number071103
JournalApplied Physics Letters
Volume109
Issue number7
DOIs
StatePublished - Aug 15 2016

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laser cavities
bioinstrumentation
photonics
crystals
wavelengths
proteins
shift
immobilization
figure of merit
narrowband
molecules
electromagnetic fields
slabs
refractivity
porosity
fabrication
sensors
interactions

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Porous photonic crystal external cavity laser biosensor. / Huang, Qinglan; Peh, Jessie; Hergenrother, Paul J.; Cunningham, Brian T.

In: Applied Physics Letters, Vol. 109, No. 7, 071103, 15.08.2016.

Research output: Contribution to journalArticle

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