TY - JOUR
T1 - Porcine reproductive and respiratory syndrome virus (PRRSV)
T2 - Pathogenesis and interaction with the immune system
AU - Lunney, Joan K.
AU - Fang, Ying
AU - Ladinig, Andrea
AU - Chen, Nanhua
AU - Li, Yanhua
AU - Rowland, Bob
AU - Renukaradhya, Gourapura J.
N1 - Publisher Copyright:
Copyright © 2016 by Annual Reviews. All rights reserved.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - This review addresses important issues of porcine reproductive and respiratory syndrome virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most economically important infectious disease of pigs. We highlight the latest information on viral genome structure, pathogenic mechanisms, and host immunity, with a special focus on immune factors that modulate PRRSV infections during the acute and chronic/persistent disease phases. We address genetic control of host resistance and probe effects of PRRSV infection on reproductive traits. A major goal is to identify cellular/viral targets and pathways for designing more effective vaccines and therapeutics. Based on progress in viral reverse genetics, host transcriptomics and genomics, and vaccinology and adjuvant technologies, we have identified new areas for PRRS control and prevention. Finally, we highlight the gaps in our knowledge base and the need for advanced molecular and immune tools to stimulate PRRS research and field applications.
AB - This review addresses important issues of porcine reproductive and respiratory syndrome virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most economically important infectious disease of pigs. We highlight the latest information on viral genome structure, pathogenic mechanisms, and host immunity, with a special focus on immune factors that modulate PRRSV infections during the acute and chronic/persistent disease phases. We address genetic control of host resistance and probe effects of PRRSV infection on reproductive traits. A major goal is to identify cellular/viral targets and pathways for designing more effective vaccines and therapeutics. Based on progress in viral reverse genetics, host transcriptomics and genomics, and vaccinology and adjuvant technologies, we have identified new areas for PRRS control and prevention. Finally, we highlight the gaps in our knowledge base and the need for advanced molecular and immune tools to stimulate PRRS research and field applications.
KW - Fetal infection
KW - Genetic control
KW - Host immunity
KW - PRRSV
KW - Porcine reproductive and respiratory syndrome
KW - Vaccine responses
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U2 - 10.1146/annurev-animal-022114-111025
DO - 10.1146/annurev-animal-022114-111025
M3 - Review article
C2 - 26646630
AN - SCOPUS:84959058063
SN - 2165-8102
VL - 4
SP - 129
EP - 154
JO - Annual Review of Animal Biosciences
JF - Annual Review of Animal Biosciences
ER -