TY - JOUR
T1 - Porcine reproductive and respiratory syndrome virus (PRRSV)
T2 - Pathogenesis and interaction with the immune system
AU - Lunney, Joan K.
AU - Fang, Ying
AU - Ladinig, Andrea
AU - Chen, Nanhua
AU - Li, Yanhua
AU - Rowland, Bob
AU - Renukaradhya, Gourapura J.
N1 - Funding Information:
We would like to acknowledge the contributions of our porcine reproductive and respiratory syndrome (PRRS) research colleagues who have produced the work highlighted in this review. Space and citation limitations prevented us from providing a complete review of the PRRS literature; recent US National Pork Board–funded literature reviews provide excellent additional background data and analyses (31, 39, 149). Thus, we have cited recent reviews and the most important references and developments in PRRS virology, pathogenesis, and immunology. Our literature review was completed in May 2015. The authors acknowledge funding support for their research from the US Department of Agriculture Agricultural Research Service and National Institute of Food and Agriculture, the US National Pork Board, and Genome Canada.
Publisher Copyright:
Copyright © 2016 by Annual Reviews. All rights reserved.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - This review addresses important issues of porcine reproductive and respiratory syndrome virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most economically important infectious disease of pigs. We highlight the latest information on viral genome structure, pathogenic mechanisms, and host immunity, with a special focus on immune factors that modulate PRRSV infections during the acute and chronic/persistent disease phases. We address genetic control of host resistance and probe effects of PRRSV infection on reproductive traits. A major goal is to identify cellular/viral targets and pathways for designing more effective vaccines and therapeutics. Based on progress in viral reverse genetics, host transcriptomics and genomics, and vaccinology and adjuvant technologies, we have identified new areas for PRRS control and prevention. Finally, we highlight the gaps in our knowledge base and the need for advanced molecular and immune tools to stimulate PRRS research and field applications.
AB - This review addresses important issues of porcine reproductive and respiratory syndrome virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most economically important infectious disease of pigs. We highlight the latest information on viral genome structure, pathogenic mechanisms, and host immunity, with a special focus on immune factors that modulate PRRSV infections during the acute and chronic/persistent disease phases. We address genetic control of host resistance and probe effects of PRRSV infection on reproductive traits. A major goal is to identify cellular/viral targets and pathways for designing more effective vaccines and therapeutics. Based on progress in viral reverse genetics, host transcriptomics and genomics, and vaccinology and adjuvant technologies, we have identified new areas for PRRS control and prevention. Finally, we highlight the gaps in our knowledge base and the need for advanced molecular and immune tools to stimulate PRRS research and field applications.
KW - Fetal infection
KW - Genetic control
KW - Host immunity
KW - PRRSV
KW - Porcine reproductive and respiratory syndrome
KW - Vaccine responses
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U2 - 10.1146/annurev-animal-022114-111025
DO - 10.1146/annurev-animal-022114-111025
M3 - Review article
C2 - 26646630
AN - SCOPUS:84959058063
SN - 2165-8102
VL - 4
SP - 129
EP - 154
JO - Annual Review of Animal Biosciences
JF - Annual Review of Animal Biosciences
ER -