TY - JOUR
T1 - Pontine and thalamic influences on fluid rewards
T2 - II. Sucrose and corn oil conditioned aversions
AU - Liang, Nu Chu
AU - Grigson, Patricia S.
AU - Norgren, Ralph
N1 - Funding Information:
Supported by NIH grants DC00240 , DK 079182 , and DA012473 as well as a PA State Tobacco Settlement Award . The authors thank H. Li for surgical assistance,and K. Matayas and N. Horvath for histology.
PY - 2012/1/18
Y1 - 2012/1/18
N2 - In this study conditioned aversions were produced in sham feeding rats to limit postingestive feedback from the oral stimulus. All control rats learned an aversion to either 100% corn oil or 0.3. M sucrose when ingestion of these stimuli was followed by an injection of lithium chloride (LiCl). Rats with lesions of the ventroposteromedial thalamus also learned to avoid either corn oil or sucrose. After 3 trials, rats with damage to the parabrachial nuclei (PBN) learned to avoid 100% corn oil, but failed to do so when the stimulus was 0.3. M sucrose. These results support our hypothesis that the PBN is necessary to appropriately respond to a taste, but not an oil cue as a function of experience (i.e., pairings with LiCl). The results also are consistent with our results from operant tasks demonstrating that the trigeminal thalamus, the ventroposteromedial nucleus, is not required for responding to the rewarding properties of sucrose, oil, or for modifying the response to these stimuli as a function of experience.
AB - In this study conditioned aversions were produced in sham feeding rats to limit postingestive feedback from the oral stimulus. All control rats learned an aversion to either 100% corn oil or 0.3. M sucrose when ingestion of these stimuli was followed by an injection of lithium chloride (LiCl). Rats with lesions of the ventroposteromedial thalamus also learned to avoid either corn oil or sucrose. After 3 trials, rats with damage to the parabrachial nuclei (PBN) learned to avoid 100% corn oil, but failed to do so when the stimulus was 0.3. M sucrose. These results support our hypothesis that the PBN is necessary to appropriately respond to a taste, but not an oil cue as a function of experience (i.e., pairings with LiCl). The results also are consistent with our results from operant tasks demonstrating that the trigeminal thalamus, the ventroposteromedial nucleus, is not required for responding to the rewarding properties of sucrose, oil, or for modifying the response to these stimuli as a function of experience.
KW - Conditioned taste aversion
KW - Corn oil
KW - Parabrachial nucleus
KW - Sham feeding
KW - Sucrose
KW - Ventroposteromedial nucleus
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U2 - 10.1016/j.physbeh.2011.06.009
DO - 10.1016/j.physbeh.2011.06.009
M3 - Article
C2 - 21699909
AN - SCOPUS:82155167687
SN - 0031-9384
VL - 105
SP - 589
EP - 594
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 2
ER -