Pontine and thalamic influences on fluid rewards: II. Sucrose and corn oil conditioned aversions

Nu Chu Liang, Patricia S. Grigson, Ralph Norgren

Research output: Contribution to journalArticlepeer-review


In this study conditioned aversions were produced in sham feeding rats to limit postingestive feedback from the oral stimulus. All control rats learned an aversion to either 100% corn oil or 0.3. M sucrose when ingestion of these stimuli was followed by an injection of lithium chloride (LiCl). Rats with lesions of the ventroposteromedial thalamus also learned to avoid either corn oil or sucrose. After 3 trials, rats with damage to the parabrachial nuclei (PBN) learned to avoid 100% corn oil, but failed to do so when the stimulus was 0.3. M sucrose. These results support our hypothesis that the PBN is necessary to appropriately respond to a taste, but not an oil cue as a function of experience (i.e., pairings with LiCl). The results also are consistent with our results from operant tasks demonstrating that the trigeminal thalamus, the ventroposteromedial nucleus, is not required for responding to the rewarding properties of sucrose, oil, or for modifying the response to these stimuli as a function of experience.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalPhysiology and Behavior
Issue number2
StatePublished - Jan 18 2012
Externally publishedYes


  • Conditioned taste aversion
  • Corn oil
  • Parabrachial nucleus
  • Sham feeding
  • Sucrose
  • Ventroposteromedial nucleus

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


Dive into the research topics of 'Pontine and thalamic influences on fluid rewards: II. Sucrose and corn oil conditioned aversions'. Together they form a unique fingerprint.

Cite this