Polypyrrole nanospheres with magnetic and cell-targeting capabilities

Shy Chyi Wuang, Koon Gee Neoh, En Tang Kang, Daniel W. Pack, Deborah E. Leckband

Research output: Contribution to journalArticle

Abstract

The preparation of polypyrrole/Fe3O4 nanospheres by a facile mini-emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well-dispersed nanospheres of 80-100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe3O 4 nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells.

Original languageEnglish (US)
Pages (from-to)816-821
Number of pages6
JournalMacromolecular Rapid Communications
Volume28
Issue number7
DOIs
StatePublished - Apr 2 2007

Keywords

  • Cancer cell-targeting
  • Emulsion polymerization
  • Hyaluronic acid
  • Polypyrrole/FeO nanospheres
  • Surfactants

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

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