Polypyrrole nanospheres with magnetic and cell-targeting capabilities

Shy Chyi Wuang, Koon Gee Neoh, En Tang Kang, Daniel W. Pack, Deborah E. Leckband

Research output: Contribution to journalArticle

Abstract

The preparation of polypyrrole/Fe3O4 nanospheres by a facile mini-emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well-dispersed nanospheres of 80-100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe3O 4 nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells.

Original languageEnglish (US)
Pages (from-to)816-821
Number of pages6
JournalMacromolecular Rapid Communications
Volume28
Issue number7
DOIs
StatePublished - Apr 2 2007

Fingerprint

Nanospheres
Polypyrroles
Hyaluronic acid
Hyaluronic Acid
Surface-Active Agents
Surface active agents
Emulsion polymerization
Polyethylene oxides
Biocompatibility
Antibodies
Functional groups
Polyethylene glycols
Adhesives
Alcohols
Cells
Availability
Molecules
polypyrrole
Trastuzumab

Keywords

  • Cancer cell-targeting
  • Emulsion polymerization
  • Hyaluronic acid
  • Polypyrrole/FeO nanospheres
  • Surfactants

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

Cite this

Polypyrrole nanospheres with magnetic and cell-targeting capabilities. / Wuang, Shy Chyi; Neoh, Koon Gee; Kang, En Tang; Pack, Daniel W.; Leckband, Deborah E.

In: Macromolecular Rapid Communications, Vol. 28, No. 7, 02.04.2007, p. 816-821.

Research output: Contribution to journalArticle

Wuang, Shy Chyi ; Neoh, Koon Gee ; Kang, En Tang ; Pack, Daniel W. ; Leckband, Deborah E. / Polypyrrole nanospheres with magnetic and cell-targeting capabilities. In: Macromolecular Rapid Communications. 2007 ; Vol. 28, No. 7. pp. 816-821.
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