Polyphosphate, platelets, and coagulation

R. J. Travers, S. A. Smith, J. H. Morrissey

Research output: Contribution to journalReview article

Abstract

While we have understood the basic outline of the enzymes and reactions that make up the traditional blood coagulation cascade for many years, recently our appreciation of the complexity of these interactions has greatly increased. This has resulted in unofficial 'revisions' of the coagulation cascade to include new amplification pathways and connections between the standard coagulation cascade enzymes, as well as the identification of extensive connections between the immune system and the coagulation cascade. The discovery that polyphosphate is stored in platelet dense granules and is secreted during platelet activation has resulted in a recent burst of interest in the role of this ancient molecule in human biology. Here we review the increasingly complex role of platelet polyphosphate in hemostasis, thrombosis, and inflammation that has been uncovered in recent years, as well as novel therapeutics centered on modulating polyphosphate's roles in coagulation and inflammation.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalInternational Journal of Laboratory Hematology
Volume37
Issue numberS1
DOIs
StatePublished - May 1 2015

Keywords

  • Coagulation
  • Hemostasis
  • Platelets
  • Polyphosphate
  • Thrombosis

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical

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