Polyphosphate as modulator of hemostasis, thrombosis, and inflammation

J. H. Morrissey, S. A. Smith

Research output: Contribution to journalReview article

Abstract

Inorganic polyphosphate (polyP), a linear polymer of phosphates, is present in many infectious microorganisms and is secreted by mast cells and platelets. PolyP has recently been shown to accelerate blood clotting and slow fibrinolysis, in a manner that is highly dependent on polymer length. Very long-chain polyP (of the type present in microorganisms) is an especially potent trigger of the contact pathway, enhances the proinflammatory activity of histones, and may participate in host responses to pathogens. PolyP also inhibits complement, providing another link between polyP and inflammation/innate immunity. Platelet-size polyP (which is considerably shorter) accelerates factor V activation, opposes the anticoagulant action of tissue factor pathway inhibitor, modulates fibrin clot structure, and promotes factor XI activation. PolyP may have utility in treating bleeding. It is also a potential target for the development of antithrombotic drugs with a novel mechanism of action and potentially fewer bleeding side effects compared with conventional anticoagulants.

Original languageEnglish (US)
Pages (from-to)S92-S97
JournalJournal of Thrombosis and Haemostasis
Volume13
Issue numberS1
DOIs
StatePublished - Jun 1 2015

Fingerprint

Polyphosphates
Hemostasis
Thrombosis
Polyps
Inflammation
Anticoagulants
Polymers
Blood Platelets
Factor XI
Hemorrhage
Factor V
Blood Coagulation
Fibrinolysis
Fibrin
Innate Immunity
Mast Cells
Histones
Phosphates
Pharmaceutical Preparations

Keywords

  • Blood coagulation
  • Coagulation factor XI
  • Inflammation
  • Kallikrein-kinin system
  • Platelets
  • Polyphosphates

ASJC Scopus subject areas

  • Hematology

Cite this

Polyphosphate as modulator of hemostasis, thrombosis, and inflammation. / Morrissey, J. H.; Smith, S. A.

In: Journal of Thrombosis and Haemostasis, Vol. 13, No. S1, 01.06.2015, p. S92-S97.

Research output: Contribution to journalReview article

Morrissey, J. H. ; Smith, S. A. / Polyphosphate as modulator of hemostasis, thrombosis, and inflammation. In: Journal of Thrombosis and Haemostasis. 2015 ; Vol. 13, No. S1. pp. S92-S97.
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