Polyphosphate: An ancient molecule that links platelets, coagulation, and inflammation

James H. Morrissey, Sharon H. Choi, Stephanie A. Smith

Research output: Contribution to journalReview article

Abstract

Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic activator of the contact pathway of blood clotting. Medium-chain polyphosphate (of the size secreted from activated human platelets) accelerates factor V activation, completely abrogates the anticoagulant function of tissue factor pathway inhibitor, enhances fibrin clot structure, and greatly accelerates factor XI activation by thrombin. Polyphosphate may have utility as a hemostatic agent, whereas antagonists of polyphosphate may function as novel antithrombotic/antiinflammatory agents. The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated.

Original languageEnglish (US)
Pages (from-to)5972-5979
Number of pages8
JournalBlood
Volume119
Issue number25
DOIs
StatePublished - Jun 21 2012

Fingerprint

Polyphosphates
Platelets
Coagulation
Blood Platelets
Inflammation
Molecules
Blood Coagulation
Blood
Chemical activation
Factor XI
Fibrinolytic Agents
Hemostatics
Fibrin
Thrombin
Microorganisms
Anticoagulants
Anti-Inflammatory Agents

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Polyphosphate : An ancient molecule that links platelets, coagulation, and inflammation. / Morrissey, James H.; Choi, Sharon H.; Smith, Stephanie A.

In: Blood, Vol. 119, No. 25, 21.06.2012, p. 5972-5979.

Research output: Contribution to journalReview article

Morrissey, James H. ; Choi, Sharon H. ; Smith, Stephanie A. / Polyphosphate : An ancient molecule that links platelets, coagulation, and inflammation. In: Blood. 2012 ; Vol. 119, No. 25. pp. 5972-5979.
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