Polynucleotide constructs for increased lysine production

Lhing-Yew Li (Inventor), Kelli Jean Trei (Inventor)

Research output: Patent


The invention relates to production of lysine, and provides several isolated polynucleotide molecules useful for the production of L-lysine. One such polynucleotide encodes an aspartate kinase (ask), an aspartate-semialdehyde dehydrogenase (asd) and a dihydrodipicolinate reductase (dapB). Other polypeptides encode ask, asd, dapB and a diaminopimelate dehydrogenase (ddh); ask, asd, dapB, ddh and an ORF2 poypeptide; and ask, asd dapB, ddh, ORF2 and a diaminopimelate decarboxylase (lysA). The invention further provides methods of making and using the polynucleotides, and methods to increase the production of L-lysine.
Original languageEnglish (US)
U.S. patent number8685719
IPCC12N 15/00
StatePublished - Apr 1 2014
Externally publishedYes


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