Polyelectrolyte theory and chromatin-DNA quaternary structure: Role of ionic strength and Hl histone

A. Belmont, C. Nicolini

Research output: Contribution to journalArticle

Abstract

Under the assumptions outlined in this paper and those of Manning's theory of polyelectrolyte screening the electrostatic interaction of histone 1 and DNA is examined and shown to lead to spontaneous bending of DNA. Critical variables for this bending are the ionic strength, the length of DNA interacting with each histone 1 molecule, and the fraction of DNA phosphate charges neutralized by the histone 1 molecule. This interaction is postulated as accounting for the observed folding of polynucleosomes into the "solenoid" regular structure. Wherever possible comparison is made between theoretical predictions and available experimental results. Finally, biological implications are briefly discussed.

Original languageEnglish (US)
Pages (from-to)169-179
Number of pages11
JournalJournal of Theoretical Biology
Volume90
Issue number2
DOIs
StatePublished - May 21 1981
Externally publishedYes

Fingerprint

Polyelectrolytes
Chromatin
ionic strength
Ionic strength
histones
Histones
Osmolar Concentration
chromatin
DNA
Molecules
Solenoid
Folding
Phosphate
Interaction
Electrostatics
Screening
Charge
solenoids
nucleosomes
electrostatic interactions

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Polyelectrolyte theory and chromatin-DNA quaternary structure : Role of ionic strength and Hl histone. / Belmont, A.; Nicolini, C.

In: Journal of Theoretical Biology, Vol. 90, No. 2, 21.05.1981, p. 169-179.

Research output: Contribution to journalArticle

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