TY - JOUR
T1 - Poly(ADP-ribose) makes a date with death
AU - Heeres, James T.
AU - Hergenrother, Paul J.
PY - 2007/12
Y1 - 2007/12
N2 - Poly(ADP-ribose) polymerase (PARP) enzymes catalyze the conversion of NAD+ to polymers of poly(ADP-ribose) (PAR). Although its role in the DNA-damage response has long been recognized, recent work indicates that PAR itself acts at the mitochondria to directly induce cell death through stimulation of apoptosis-inducing factor (AIF) release. This review discusses PAR synthesis and degradation, and the role of PAR misregulation in various disease states. Attention is given to opportunities for therapeutic intervention with small molecules that are involved in PAR signaling, with specific focus on poly(ADP-ribose) glycohydrolase (PARG) and AIF.
AB - Poly(ADP-ribose) polymerase (PARP) enzymes catalyze the conversion of NAD+ to polymers of poly(ADP-ribose) (PAR). Although its role in the DNA-damage response has long been recognized, recent work indicates that PAR itself acts at the mitochondria to directly induce cell death through stimulation of apoptosis-inducing factor (AIF) release. This review discusses PAR synthesis and degradation, and the role of PAR misregulation in various disease states. Attention is given to opportunities for therapeutic intervention with small molecules that are involved in PAR signaling, with specific focus on poly(ADP-ribose) glycohydrolase (PARG) and AIF.
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U2 - 10.1016/j.cbpa.2007.08.038
DO - 10.1016/j.cbpa.2007.08.038
M3 - Review article
C2 - 17936669
AN - SCOPUS:36549082920
SN - 1367-5931
VL - 11
SP - 644
EP - 653
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 6
ER -