Abstract

Point-of-care sensors that enable the fast collection of information relevant to a patient’s health state can facilitate improved health access, reduce healthcare costs and improve the quality of healthcare delivery. In the diagnosis of sepsis — defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, and the leading cause of in-patient death and of hospital readmission in the United States — predicting which infections will lead to life-threatening organ dysfunction and developing specific anti-sepsis treatments remain challenging because of the significant heterogeneity of the host response. Yet the use of point-of-care devices could reduce the time from the onset of a patient’s infection to the administration of appropriate therapeutics. In this Perspective, we describe the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outline opportunities in the use of these devices to dramatically improve patient care.

Original languageEnglish (US)
Pages (from-to)640-648
Number of pages9
JournalNature biomedical engineering
Volume2
Issue number9
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

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  • Cite this

    Reddy, B., Hassan, U., Seymour, C., Angus, D. C., Isbell, T. S., White, K., Weir, W., Yeh, L., Vincent, A., & Bashir, R. (2018). Point-of-care sensors for the management of sepsis. Nature biomedical engineering, 2(9), 640-648. https://doi.org/10.1038/s41551-018-0288-9