Abstract

Point-of-care sensors that enable the fast collection of information relevant to a patient’s health state can facilitate improved health access, reduce healthcare costs and improve the quality of healthcare delivery. In the diagnosis of sepsis — defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, and the leading cause of in-patient death and of hospital readmission in the United States — predicting which infections will lead to life-threatening organ dysfunction and developing specific anti-sepsis treatments remain challenging because of the significant heterogeneity of the host response. Yet the use of point-of-care devices could reduce the time from the onset of a patient’s infection to the administration of appropriate therapeutics. In this Perspective, we describe the current state of point-of-care sensors for the diagnosis and monitoring of sepsis, and outline opportunities in the use of these devices to dramatically improve patient care.

Original languageEnglish (US)
Pages (from-to)640-648
Number of pages9
JournalNature biomedical engineering
Volume2
Issue number9
DOIs
StatePublished - Sep 1 2018

Fingerprint

Point-of-Care Systems
Sepsis
Health
Sensors
Infection
Patient Readmission
Equipment and Supplies
Quality of Health Care
Health Care Costs
Monitoring
Patient Care
Delivery of Health Care
Costs
Therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Reddy, B., Hassan, U., Seymour, C., Angus, D. C., Isbell, T. S., White, K., ... Bashir, R. (2018). Point-of-care sensors for the management of sepsis. Nature biomedical engineering, 2(9), 640-648. https://doi.org/10.1038/s41551-018-0288-9

Point-of-care sensors for the management of sepsis. / Reddy, B.; Hassan, U.; Seymour, C.; Angus, D. C.; Isbell, T. S.; White, K.; Weir, W.; Yeh, L.; Vincent, A.; Bashir, Rashid.

In: Nature biomedical engineering, Vol. 2, No. 9, 01.09.2018, p. 640-648.

Research output: Contribution to journalReview article

Reddy, B, Hassan, U, Seymour, C, Angus, DC, Isbell, TS, White, K, Weir, W, Yeh, L, Vincent, A & Bashir, R 2018, 'Point-of-care sensors for the management of sepsis', Nature biomedical engineering, vol. 2, no. 9, pp. 640-648. https://doi.org/10.1038/s41551-018-0288-9
Reddy B, Hassan U, Seymour C, Angus DC, Isbell TS, White K et al. Point-of-care sensors for the management of sepsis. Nature biomedical engineering. 2018 Sep 1;2(9):640-648. https://doi.org/10.1038/s41551-018-0288-9
Reddy, B. ; Hassan, U. ; Seymour, C. ; Angus, D. C. ; Isbell, T. S. ; White, K. ; Weir, W. ; Yeh, L. ; Vincent, A. ; Bashir, Rashid. / Point-of-care sensors for the management of sepsis. In: Nature biomedical engineering. 2018 ; Vol. 2, No. 9. pp. 640-648.
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