Plasmonic Sensing of Oncoproteins without Resonance Shift Using 3D Periodic Nanocavity in Nanocup Arrays

Abid Ameen; Lisa P. Hackett; Sujin Seo; Faiza Khawar Dar; Manas R. Gartia; Lynford L. Goddard; Gang Logan Liu

doi:10.1002/adom.201601051

Plasmonic Sensing of Oncoproteins without Resonance Shift Using 3D Periodic Nanocavity in Nanocup Arrays

Abid Ameen, Lisa P. Hackett, Sujin Seo, Faiza Khawar Dar, Manas R. Gartia, Lynford L. Goddard, Gang Logan Liu

Research output: Contribution to journal › Article › peer-review

Abstract

A sensor design and sensing method based on plasmonic–photonic interactions that occur when a nanocavity array is embedded in a 3D tapered nanocup plasmonic substrate are reported. This device enables highly sensitive detection of refractive index changes based on changes to the transmission peak intensity without shift in the resonance wavelength. Unlike conventional plasmonic sensors, there is a consistent and selective change in the transmission intensity at the resonance peak wavelength with no spectral shift. In addition, there are wavelength ranges that show no intensity change, which can be used as reference regions. The fabrication and characterization of the plasmonic nanocavity sensor are described and also advanced biosensing is demonstrated. Simulations are carried out to better understand the plasmon–photonic coupling mechanism. This nanocavity plasmonic sensor design has a limit of detection of 1 ng mL⁻¹ (5 × 10⁻¹²m) for the cancer biomarker carcinoembryonic antigen (CEA), which is a significant improvement over current surface plasmon resonance systems, and a dynamic range that is clinically relevant for human CEA levels.

Original language	English (US)
Article number	1601051
Journal	Advanced Optical Materials
Volume	5
Issue number	11
DOIs	https://doi.org/10.1002/adom.201601051
State	Published - Jun 2 2017

Keywords

carcinoembryonic antigens
extraordinary optical transmission
nanohole array sensors
nanostructure fabrication
surface plasmon resonance

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

Online availability

10.1002/adom.201601051

Library availability

Discover UIUC Full Text

Cite this

@article{aa90916e1fa144a7abbbd5dbb3275531,

title = "Plasmonic Sensing of Oncoproteins without Resonance Shift Using 3D Periodic Nanocavity in Nanocup Arrays",

abstract = "A sensor design and sensing method based on plasmonic–photonic interactions that occur when a nanocavity array is embedded in a 3D tapered nanocup plasmonic substrate are reported. This device enables highly sensitive detection of refractive index changes based on changes to the transmission peak intensity without shift in the resonance wavelength. Unlike conventional plasmonic sensors, there is a consistent and selective change in the transmission intensity at the resonance peak wavelength with no spectral shift. In addition, there are wavelength ranges that show no intensity change, which can be used as reference regions. The fabrication and characterization of the plasmonic nanocavity sensor are described and also advanced biosensing is demonstrated. Simulations are carried out to better understand the plasmon–photonic coupling mechanism. This nanocavity plasmonic sensor design has a limit of detection of 1 ng mL−1 (5 × 10−12m) for the cancer biomarker carcinoembryonic antigen (CEA), which is a significant improvement over current surface plasmon resonance systems, and a dynamic range that is clinically relevant for human CEA levels.",

keywords = "carcinoembryonic antigens, extraordinary optical transmission, nanohole array sensors, nanostructure fabrication, surface plasmon resonance",

author = "Abid Ameen and Hackett, {Lisa P.} and Sujin Seo and Dar, {Faiza Khawar} and Gartia, {Manas R.} and Goddard, {Lynford L.} and Liu, {Gang Logan}",

note = "Funding Information: A.A., L.P.H., and S.S. contributed equally to this work. This work was funded by the U.S. Department of Agriculture Award No. 2014-06959. Funding for L.P.H. was provided by the Linda Su-Nan Chang Sah doctoral fellowship. The authors thank Numair Ahmed for the schematic diagram. The authors also thank Hoang Nguyen, Cindy Larson, and Tiziana Bond of Lawrence Livermore National Laboratory for preparation of the master nanopillar mold. The authors also thank Micro Nanotechnology Laboratory and Frederick Seitz Materials Research Laboratory Central Facilities for providing research facilities. Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

month = jun,

day = "2",

doi = "10.1002/adom.201601051",

language = "English (US)",

volume = "5",

journal = "Advanced Optical Materials",

issn = "2195-1071",

publisher = "John Wiley & Sons, Ltd.",

number = "11",

}

TY - JOUR

T1 - Plasmonic Sensing of Oncoproteins without Resonance Shift Using 3D Periodic Nanocavity in Nanocup Arrays

AU - Ameen, Abid

AU - Hackett, Lisa P.

AU - Seo, Sujin

AU - Dar, Faiza Khawar

AU - Gartia, Manas R.

AU - Goddard, Lynford L.

AU - Liu, Gang Logan

N1 - Funding Information: A.A., L.P.H., and S.S. contributed equally to this work. This work was funded by the U.S. Department of Agriculture Award No. 2014-06959. Funding for L.P.H. was provided by the Linda Su-Nan Chang Sah doctoral fellowship. The authors thank Numair Ahmed for the schematic diagram. The authors also thank Hoang Nguyen, Cindy Larson, and Tiziana Bond of Lawrence Livermore National Laboratory for preparation of the master nanopillar mold. The authors also thank Micro Nanotechnology Laboratory and Frederick Seitz Materials Research Laboratory Central Facilities for providing research facilities. Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/6/2

Y1 - 2017/6/2

N2 - A sensor design and sensing method based on plasmonic–photonic interactions that occur when a nanocavity array is embedded in a 3D tapered nanocup plasmonic substrate are reported. This device enables highly sensitive detection of refractive index changes based on changes to the transmission peak intensity without shift in the resonance wavelength. Unlike conventional plasmonic sensors, there is a consistent and selective change in the transmission intensity at the resonance peak wavelength with no spectral shift. In addition, there are wavelength ranges that show no intensity change, which can be used as reference regions. The fabrication and characterization of the plasmonic nanocavity sensor are described and also advanced biosensing is demonstrated. Simulations are carried out to better understand the plasmon–photonic coupling mechanism. This nanocavity plasmonic sensor design has a limit of detection of 1 ng mL−1 (5 × 10−12m) for the cancer biomarker carcinoembryonic antigen (CEA), which is a significant improvement over current surface plasmon resonance systems, and a dynamic range that is clinically relevant for human CEA levels.

AB - A sensor design and sensing method based on plasmonic–photonic interactions that occur when a nanocavity array is embedded in a 3D tapered nanocup plasmonic substrate are reported. This device enables highly sensitive detection of refractive index changes based on changes to the transmission peak intensity without shift in the resonance wavelength. Unlike conventional plasmonic sensors, there is a consistent and selective change in the transmission intensity at the resonance peak wavelength with no spectral shift. In addition, there are wavelength ranges that show no intensity change, which can be used as reference regions. The fabrication and characterization of the plasmonic nanocavity sensor are described and also advanced biosensing is demonstrated. Simulations are carried out to better understand the plasmon–photonic coupling mechanism. This nanocavity plasmonic sensor design has a limit of detection of 1 ng mL−1 (5 × 10−12m) for the cancer biomarker carcinoembryonic antigen (CEA), which is a significant improvement over current surface plasmon resonance systems, and a dynamic range that is clinically relevant for human CEA levels.

KW - carcinoembryonic antigens

KW - extraordinary optical transmission

KW - nanohole array sensors

KW - nanostructure fabrication

KW - surface plasmon resonance

UR - http://www.scopus.com/inward/record.url?scp=85016586341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016586341&partnerID=8YFLogxK

U2 - 10.1002/adom.201601051

DO - 10.1002/adom.201601051

M3 - Article

AN - SCOPUS:85016586341

SN - 2195-1071

VL - 5

JO - Advanced Optical Materials

JF - Advanced Optical Materials

IS - 11

M1 - 1601051

ER -

Plasmonic Sensing of Oncoproteins without Resonance Shift Using 3D Periodic Nanocavity in Nanocup Arrays

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this