Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

Amy L. Oldenburg, Matthew N. Hansen, Alexander Wei, Stephen A. Boppart

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Plasmon-resonant gold nanorods have been demonstrated recently as contrast agents for optical coherence tomography (OCT). To evaluate their ability to produce contrast in a structurally heterogeneous environment, nanorods were injected at discrete locations into an excised sample of human breast invasive ductal carcinoma. The distribution of nanorods within the tissue was revealed using spectroscopic OCT imaging techniques, by analyzing the evolution of the backscattered light spectrum over tissue depth. We compare a variety of signal processing methods including spatial averaging and least-squares fitting to the a priori extinction spectrum of the nanorods, with the goal of optimizing the detection sensitivity to the nanorods in these tissues. Because nanorods can be conjugated with proteins specific to biomolecular targets, they may potentially be used with these imaging methods to provide molecular contrast in human tissues.

Original languageEnglish (US)
Title of host publicationMolecular Probes for Biomedical Applications II
DOIs
StatePublished - Apr 21 2008
EventMolecular Probes for Biomedical Applications II - San Jose, CA, United States
Duration: Jan 21 2008Jan 22 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6867
ISSN (Print)1605-7422

Other

OtherMolecular Probes for Biomedical Applications II
CountryUnited States
CitySan Jose, CA
Period1/21/081/22/08

    Fingerprint

Keywords

  • Contrast agents
  • Nanorods
  • Optical coherence tomography
  • Plasmon-resonance
  • Spectroscopic optical coherence tomography

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Oldenburg, A. L., Hansen, M. N., Wei, A., & Boppart, S. A. (2008). Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors. In Molecular Probes for Biomedical Applications II [68670E] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6867). https://doi.org/10.1117/12.761886