Plants and animals share functionally common bacterial virulence factors

Laurence G. Rahme, Frederick M. Ausubel, Hui Cao, Eliana Drenkard, Boyan C. Goumnerov, Gee W. Lau, Shalina Mahajan-Miklos, Julia Plotnikova, Man Wah Tan, John Tsongalis, Cynthia L. Walendziewicz, Ronald G. Tompkins

Research output: Contribution to journalArticle

Abstract

By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remarkable degree of conservation in the virulence mechanisms used by P. aeruginosa to infect hosts of divergent evolutionary origins.

Original languageEnglish (US)
Pages (from-to)8815-8821
Number of pages7
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number16
DOIs
StatePublished - Aug 1 2000

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    Rahme, L. G., Ausubel, F. M., Cao, H., Drenkard, E., Goumnerov, B. C., Lau, G. W., Mahajan-Miklos, S., Plotnikova, J., Tan, M. W., Tsongalis, J., Walendziewicz, C. L., & Tompkins, R. G. (2000). Plants and animals share functionally common bacterial virulence factors. Proceedings of the National Academy of Sciences of the United States of America, 97(16), 8815-8821. https://doi.org/10.1073/pnas.97.16.8815