Plant-based vaccines against the human immunodeficiency virus

Sergio Rosales-Mendoza, Dania O. Govea-Alonso, Jorge A. Salazar-González, Schuyler S. Korban

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The spread of the human immunodeficiency virus (HIV) has evolved in an alarming manner in terms of human mortality and morbidity, and thus development of an effective and affordable vaccine is a priority to fight this viral disease. As candidate vaccines assessed in clinical trials have shown limited efficacies, efforts to test new candidates capable of inducing strong and neutralizing humoral and cellular responses are underway. This chapter presents a general overview of vaccine candidates produced in plant systems, focusing on the most advanced and promising approaches. This group of candidates comprise strategies targeting structural (Env, Gag) and early non-structural HIV-1 proteins (Rev, Tat, and Nef), which have been expressed in plant tissues using a variety of expression approaches. A number of plant-based vaccines are in preclinical evaluation trials with promising results in terms of immunogenicity.

Original languageEnglish (US)
Title of host publicationGenetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases
Subtitle of host publicationAn Integrated View
PublisherSpringer New York
Pages161-173
Number of pages13
ISBN (Electronic)9781493908509
ISBN (Print)1493908499, 9781493908493
DOIs
StatePublished - Mar 1 2014

Keywords

  • AIDS
  • Cytotoxic immune response
  • ENV
  • Gag
  • Genetic variability
  • HIV-neutralizing antibodies
  • Molecular farming
  • Tat

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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