Planning and real-time monitoring of low intensity focused ultrasound therapies using a diagnostic imaging array

Miles Thies, Michael L. Oelze

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A growing number of focused ultrasound (FUS) therapies use low intensity FUS with microbubbles to induce mechanical bioeffects for the non-invasive treatment of localized tissue regions. For these low intensity mechanical-based FUS therapies, there is a need for therapy planning and real-time monitoring techniques to ensure that the FUS beam is targeted to the desired region even in the presence of tissue motion. In this work, a system is presented for combined therapy planning, low intensity FUS treatment, and real-time therapy monitoring using a single diagnostic imaging array. First, a sonication pattern was determined by manually segmenting the treatment region from a B-mode image captured with the imaging array. To visualize the FUS therapy beam, a focused pulse excitation was transmitted and backscattered signals were used to reconstruct the intensity field of the FUS beam. The FUS beam reconstruction was overlaid onto a co-aligned B-mode image captured with the imaging array, allowing one to qualitatively monitor the position and size of the FUS beam with anatomical context from the B-mode image. Real-time beam visualizations at a frame rate of 25-30 frames per second were achieved in a rat tumor in vivo and a mock FUS therapy was planned and monitored in a tissue-mimicking phantom.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2021
Subtitle of host publicationUltrasonic Imaging and Tomography
EditorsBrett C. Byram, Nicole V. Ruiter
PublisherSPIE
ISBN (Electronic)9781510640337
DOIs
StatePublished - 2021
EventMedical Imaging 2021: Ultrasonic Imaging and Tomography - Virtual, Online, United States
Duration: Feb 15 2021Feb 19 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11602
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2021: Ultrasonic Imaging and Tomography
CountryUnited States
CityVirtual, Online
Period2/15/212/19/21

Keywords

  • Beam visualization
  • Focused ultrasound
  • Therapy monitoring
  • Therapy planning

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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