Pituitary-ovary-spleen axis in ovulation

Oliver R. Oakley; Michele L. Frazer; Che Myong Ko

doi:10.1016/j.tem.2011.04.005

Pituitary-ovary-spleen axis in ovulation

Oliver R. Oakley, Michele L. Frazer, Che Myong Ko

Research output: Contribution to journal › Review article › peer-review

Abstract

Leukocytes are rapidly recruited to the preovulatory ovary and play a crucial role as facilitators of ovulation and luteal formation. In this article, recent findings on leukocyte trafficking to the ovary, as well as the physiological role of leukocytes in the ovary, will be summarized and discussed. We then explore the novel hypothesis that the hypothalamus-pituitary-ovary (HPO) axis might include the spleen as a reservoir of leukocytes by summarizing recent reports on this topic, both in the fields of immunology and reproductive biology.

Original language	English (US)
Pages (from-to)	345-352
Number of pages	8
Journal	Trends in Endocrinology and Metabolism
Volume	22
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2011.04.005
State	Published - Sep 2011

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2011.04.005

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title = "Pituitary-ovary-spleen axis in ovulation",

abstract = "Leukocytes are rapidly recruited to the preovulatory ovary and play a crucial role as facilitators of ovulation and luteal formation. In this article, recent findings on leukocyte trafficking to the ovary, as well as the physiological role of leukocytes in the ovary, will be summarized and discussed. We then explore the novel hypothesis that the hypothalamus-pituitary-ovary (HPO) axis might include the spleen as a reservoir of leukocytes by summarizing recent reports on this topic, both in the fields of immunology and reproductive biology.",

author = "Oakley, {Oliver R.} and Frazer, {Michele L.} and Ko, {Che Myong}",

note = "Funding Information: We thank Dr. Thomas E. Curry for critical comments and Mr. Tom Dolan for the artwork. This work was supported by National Institutes of Health grant RO1HD052694 (to C.K.).",

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AU - Frazer, Michele L.

AU - Ko, Che Myong

N1 - Funding Information: We thank Dr. Thomas E. Curry for critical comments and Mr. Tom Dolan for the artwork. This work was supported by National Institutes of Health grant RO1HD052694 (to C.K.).

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N2 - Leukocytes are rapidly recruited to the preovulatory ovary and play a crucial role as facilitators of ovulation and luteal formation. In this article, recent findings on leukocyte trafficking to the ovary, as well as the physiological role of leukocytes in the ovary, will be summarized and discussed. We then explore the novel hypothesis that the hypothalamus-pituitary-ovary (HPO) axis might include the spleen as a reservoir of leukocytes by summarizing recent reports on this topic, both in the fields of immunology and reproductive biology.

AB - Leukocytes are rapidly recruited to the preovulatory ovary and play a crucial role as facilitators of ovulation and luteal formation. In this article, recent findings on leukocyte trafficking to the ovary, as well as the physiological role of leukocytes in the ovary, will be summarized and discussed. We then explore the novel hypothesis that the hypothalamus-pituitary-ovary (HPO) axis might include the spleen as a reservoir of leukocytes by summarizing recent reports on this topic, both in the fields of immunology and reproductive biology.

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Pituitary-ovary-spleen axis in ovulation

Abstract

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