Pituitary-ovary-spleen axis in ovulation

Oliver R. Oakley, Michele L. Frazer, Che Myong Ko

Research output: Contribution to journalReview articlepeer-review


Leukocytes are rapidly recruited to the preovulatory ovary and play a crucial role as facilitators of ovulation and luteal formation. In this article, recent findings on leukocyte trafficking to the ovary, as well as the physiological role of leukocytes in the ovary, will be summarized and discussed. We then explore the novel hypothesis that the hypothalamus-pituitary-ovary (HPO) axis might include the spleen as a reservoir of leukocytes by summarizing recent reports on this topic, both in the fields of immunology and reproductive biology.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalTrends in Endocrinology and Metabolism
Issue number9
StatePublished - Sep 2011
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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