TY - JOUR
T1 - Physical activity-related individual differences in functional human connectome are linked to fluid intelligence in older adults
AU - Pindus, Dominika M.
AU - Ai, Meishan
AU - Chaddock-Heyman, Laura
AU - Burzynska, Agnieszka Z.
AU - Gothe, Neha P.
AU - Salerno, Elizabeth A.
AU - Fanning, Jason
AU - Arnold Anteraper, Sheeba R.A.
AU - Castanon, Alfonso N.
AU - Whitfield-Gabrieli, Susan
AU - Hillman, Charles H
AU - McAuley, Edward
AU - Kramer, Arthur F.
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/5
Y1 - 2024/5
N2 - The study examined resting state functional connectivity (rs-FC) associated with moderate-to-vigorous physical activity (MV-PA), sedentary time (ST), TV viewing, computer use, and their relationship to cognitive performance in older adults. We used pre-intervention data from 119 participants from the Fit & Active Seniors trial. Multivariate pattern analysis revealed two seeds associated with MV-PA: right superior frontal gyrus (SFG; spanning frontoparietal [FPN] and ventral attention networks [VAN]) and right precentral (PrG) and postcentral gyri (PoG) of the somatosensory network (SN). A positive correlation between the right SFG seed and a cluster spanning default mode (DMN), dorsal attention (DAN), FPN, and visual networks (VIS) was linked to higher fluid intelligence, as was FC between the right PrG/PoG seed and a cluster in VIS. No significant rs-FC patterns associated with ST, TV viewing, or computer use were found. Our findings suggest that greater functional integration within networks implementing top-down control and within those supporting visuospatial abilities, paired with segregation between networks critical and those not critical to top-down control, may help promote cognitive reserve in more physically active seniors.
AB - The study examined resting state functional connectivity (rs-FC) associated with moderate-to-vigorous physical activity (MV-PA), sedentary time (ST), TV viewing, computer use, and their relationship to cognitive performance in older adults. We used pre-intervention data from 119 participants from the Fit & Active Seniors trial. Multivariate pattern analysis revealed two seeds associated with MV-PA: right superior frontal gyrus (SFG; spanning frontoparietal [FPN] and ventral attention networks [VAN]) and right precentral (PrG) and postcentral gyri (PoG) of the somatosensory network (SN). A positive correlation between the right SFG seed and a cluster spanning default mode (DMN), dorsal attention (DAN), FPN, and visual networks (VIS) was linked to higher fluid intelligence, as was FC between the right PrG/PoG seed and a cluster in VIS. No significant rs-FC patterns associated with ST, TV viewing, or computer use were found. Our findings suggest that greater functional integration within networks implementing top-down control and within those supporting visuospatial abilities, paired with segregation between networks critical and those not critical to top-down control, may help promote cognitive reserve in more physically active seniors.
KW - Cognitive function
KW - Functional connectivity
KW - Multivariate pattern analyses
KW - Older adults
KW - Physical activity
KW - Sedentary behaviors
UR - http://www.scopus.com/inward/record.url?scp=85187351756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85187351756&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2024.02.002
DO - 10.1016/j.neurobiolaging.2024.02.002
M3 - Article
C2 - 38460470
AN - SCOPUS:85187351756
SN - 0197-4580
VL - 137
SP - 94
EP - 104
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -