Physical activity correlates with neurological impairment and disability in multiple sclerosis

Robert W. Motl, Erin M. Snook, Daniel R. Wynn, Timothy Vollmer

Research output: Contribution to journalArticlepeer-review


This study examined the correlation of physical activity with neurological impairment and disability in persons with multiple sclerosis (MS). Eighty individuals with MS wore an accelerometer for 7 days and completed the Symptom Inventory (SI), Performance Scales (PS), and Expanded Disability Status Scale. There were large negative correlations between the accelerometer and SI (r= -0.56; ρ = -0.58) and Expanded Disability Status Scale (r = -0.60; ρ = -0.69) and a moderate negative correlation between the accelerometer and PS (r=-0.39; ρ= -0.48) indicating that physical activity was associated with reduced neurological impairment and disability. Such findings provide a preliminary basis for using an accelerometer and the SI and PS as outcome measures in large-scale prospective and experimental examinations of the effect of physical activity behavior on disability and dependence in MS.

Original languageEnglish (US)
Pages (from-to)492-495
Number of pages4
JournalJournal of Nervous and Mental Disease
Issue number6
StatePublished - Jun 2008


  • Disability
  • Impairment
  • Multiple sclerosis
  • Rehabilitation

ASJC Scopus subject areas

  • Psychiatry and Mental health


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