Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

Agnieszka Zofia Burzynska; Laura Chaddock-Heyman; Michelle W. Voss; Chelsea N. Wong; Neha P. Gothe; Erin A. Olson; Anya Knecht; Andrew Lewis; Jim M. Monti; Gillian E. Cooke; Thomas R. Wojcicki; Jason Fanning; Hyondo David Chung; Elisabeth Awick; Edward McAuley; Arthur F. Kramer

doi:10.1371/journal.pone.0107413

Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

Agnieszka Zofia Burzynska, Laura Chaddock-Heyman, Michelle W. Voss, Chelsea N. Wong, Neha P. Gothe, Erin A. Olson, Anya Knecht, Andrew Lewis, Jim M. Monti, Gillian E. Cooke, Thomas R. Wojcicki, Jason Fanning, Hyondo David Chung, Elisabeth Awick, Edward McAuley, Arthur F. Kramer

Research output: Contribution to journal › Article › peer-review

Abstract

Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.

Original language	English (US)
Article number	e107413
Journal	PloS one
Volume	9
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0107413
State	Published - Sep 17 2014

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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10.1371/journal.pone.0107413

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Burzynska, A. Z., Chaddock-Heyman, L., Voss, M. W., Wong, C. N., Gothe, N. P., Olson, E. A., Knecht, A., Lewis, A., Monti, J. M., Cooke, G. E., Wojcicki, T. R., Fanning, J., Chung, H. D., Awick, E., McAuley, E., & Kramer, A. F. (2014). Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults. PloS one, 9(9), [e107413]. https://doi.org/10.1371/journal.pone.0107413

Burzynska, AZ, Chaddock-Heyman, L, Voss, MW, Wong, CN, Gothe, NP, Olson, EA, Knecht, A, Lewis, A, Monti, JM, Cooke, GE, Wojcicki, TR, Fanning, J, Chung, HD, Awick, E, McAuley, E & Kramer, AF 2014, 'Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults', PloS one, vol. 9, no. 9, e107413. https://doi.org/10.1371/journal.pone.0107413

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abstract = "Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.",

author = "Burzynska, {Agnieszka Zofia} and Laura Chaddock-Heyman and Voss, {Michelle W.} and Wong, {Chelsea N.} and Gothe, {Neha P.} and Olson, {Erin A.} and Anya Knecht and Andrew Lewis and Monti, {Jim M.} and Cooke, {Gillian E.} and Wojcicki, {Thomas R.} and Jason Fanning and Chung, {Hyondo David} and Elisabeth Awick and Edward McAuley and Kramer, {Arthur F.}",

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AU - Gothe, Neha P.

AU - Olson, Erin A.

AU - Knecht, Anya

AU - Lewis, Andrew

AU - Monti, Jim M.

AU - Cooke, Gillian E.

AU - Wojcicki, Thomas R.

AU - Fanning, Jason

AU - Chung, Hyondo David

AU - Awick, Elisabeth

AU - McAuley, Edward

AU - Kramer, Arthur F.

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Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

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