Phylogenetic comparative analysis and the secondary structure of ribonuclease P RNA - a review

Norman R. Pace; David K. Smith; Gary J. Olsen; Bryan D. James

doi:10.1016/0378-1119(89)90031-0

Phylogenetic comparative analysis and the secondary structure of ribonuclease P RNA - a review

Norman R. Pace, David K. Smith, Gary J. Olsen, Bryan D. James

Research output: Contribution to journal › Article › peer-review

Abstract

The most incisive a priori approach to inferring the higher order structure of large RNAs has proven to be the use of phylogenetic comparisons. This article provides guidelines to the method, using as an illustration the elucidation of the secondary structure of the catalytic RNA subunit of ribonuclease P (RNase P). The resultant structure is compared to the possibilities that are predicted thermodynamically for the RNase P RNA sequences of nine eubacteria.

Original language	English (US)
Pages (from-to)	65-75
Number of pages	11
Journal	Gene
Volume	82
Issue number	1
DOIs	https://doi.org/10.1016/0378-1119(89)90031-0
State	Published - Oct 15 1989
Externally published	Yes

Keywords

Catalytic RNA
RNA evolution

ASJC Scopus subject areas

Genetics

Online availability

10.1016/0378-1119(89)90031-0

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abstract = "The most incisive a priori approach to inferring the higher order structure of large RNAs has proven to be the use of phylogenetic comparisons. This article provides guidelines to the method, using as an illustration the elucidation of the secondary structure of the catalytic RNA subunit of ribonuclease P (RNase P). The resultant structure is compared to the possibilities that are predicted thermodynamically for the RNase P RNA sequences of nine eubacteria.",

keywords = "Catalytic RNA, RNA evolution",

author = "Pace, {Norman R.} and Smith, {David K.} and Olsen, {Gary J.} and James, {Bryan D.}",

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doi = "10.1016/0378-1119(89)90031-0",

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AU - Pace, Norman R.

AU - Smith, David K.

AU - Olsen, Gary J.

AU - James, Bryan D.

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PY - 1989/10/15

Y1 - 1989/10/15

N2 - The most incisive a priori approach to inferring the higher order structure of large RNAs has proven to be the use of phylogenetic comparisons. This article provides guidelines to the method, using as an illustration the elucidation of the secondary structure of the catalytic RNA subunit of ribonuclease P (RNase P). The resultant structure is compared to the possibilities that are predicted thermodynamically for the RNase P RNA sequences of nine eubacteria.

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KW - Catalytic RNA

KW - RNA evolution

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Phylogenetic comparative analysis and the secondary structure of ribonuclease P RNA - a review

Abstract

Keywords

ASJC Scopus subject areas

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