Phylogenetic comparative analysis and the secondary structure of ribonuclease P RNA - a review

Norman R. Pace, David K. Smith, Gary J. Olsen, Bryan D. James

Research output: Contribution to journalArticle

Abstract

The most incisive a priori approach to inferring the higher order structure of large RNAs has proven to be the use of phylogenetic comparisons. This article provides guidelines to the method, using as an illustration the elucidation of the secondary structure of the catalytic RNA subunit of ribonuclease P (RNase P). The resultant structure is compared to the possibilities that are predicted thermodynamically for the RNase P RNA sequences of nine eubacteria.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalGene
Volume82
Issue number1
DOIs
StatePublished - Oct 15 1989

Keywords

  • Catalytic RNA
  • RNA evolution

ASJC Scopus subject areas

  • Genetics

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