Photosensor With Multiple Light Sources

Enrico Gratton (Inventor), Scott A Walker (Inventor), John Maier (Inventor), Maria A Franceschini (Inventor), William W Mantulin (Inventor), Sergio Fantini (Inventor)

Research output: Patent

Abstract

The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example oxyhemoglobin and deoxyhemoglobin in living tissue.
Original languageEnglish (US)
U.S. patent number5497769
Filing date12/16/93
StatePublished - Mar 12 1996

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