TY - JOUR
T1 - Photonics-on-a-chip
T2 - Recent advances in integrated waveguides as enabling detection elements for real-world, lab-on-a-chip biosensing applications
AU - Washburn, Adam L.
AU - Bailey, Ryan C.
PY - 2011/1/21
Y1 - 2011/1/21
N2 - By leveraging advances in semiconductor microfabrication technologies, chip-integrated optical biosensors are poised to make an impact as scalable and multiplexable bioanalytical measurement tools for lab-on-a-chip applications. In particular, waveguide-based optical sensing technology appears to be exceptionally amenable to chip integration and miniaturization, and, as a result, the recent literature is replete with examples of chip-integrated waveguide sensing platforms developed to address a wide range of contemporary analytical challenges. As an overview of the most recent advances within this dynamic field, this review highlights work from the last 2-3 years in the areas of grating-coupled, interferometric, photonic crystal, and microresonator waveguide sensors. With a focus towards device integration, particular emphasis is placed on demonstrations of biosensing using these technologies within microfluidically controlled environments. In addition, examples of multiplexed detection and sensing within complex matrices - important features for real-world applicability - are given special attention.
AB - By leveraging advances in semiconductor microfabrication technologies, chip-integrated optical biosensors are poised to make an impact as scalable and multiplexable bioanalytical measurement tools for lab-on-a-chip applications. In particular, waveguide-based optical sensing technology appears to be exceptionally amenable to chip integration and miniaturization, and, as a result, the recent literature is replete with examples of chip-integrated waveguide sensing platforms developed to address a wide range of contemporary analytical challenges. As an overview of the most recent advances within this dynamic field, this review highlights work from the last 2-3 years in the areas of grating-coupled, interferometric, photonic crystal, and microresonator waveguide sensors. With a focus towards device integration, particular emphasis is placed on demonstrations of biosensing using these technologies within microfluidically controlled environments. In addition, examples of multiplexed detection and sensing within complex matrices - important features for real-world applicability - are given special attention.
UR - http://www.scopus.com/inward/record.url?scp=78650487407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650487407&partnerID=8YFLogxK
U2 - 10.1039/c0an00449a
DO - 10.1039/c0an00449a
M3 - Review article
C2 - 20957245
AN - SCOPUS:78650487407
SN - 0003-2654
VL - 136
SP - 227
EP - 236
JO - Analyst
JF - Analyst
IS - 2
ER -