TY - GEN
T1 - Photonic crystal optical biosensor incorporating structured low-index porous dielectric
AU - Block, Ian D.
AU - Chan, Leo L.
AU - Cunningham, Brian T.
N1 - Funding Information:
This material is based upon work supported by the National Science Foundation under Grant No. 0427657. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. The authors gratefully acknowledge SRU Biosystems for providing financial support for this work and Honeywell Electronic Materials for the donation of Nanoglass ® low-k porous dielectric material. The authors also extend their gratitude to the support staff of the Micro and Nanotechnology Laboratory at the University of Illinois at Urbana-Champaign. Ian D. Block received a BS in Electrical & Computer Engineering from Cornell University in 2004, and a MS in Electrical Engineering from the University of Illinois at Urbana-Champaign in 2005. He is currently working towards a PhD under the direction of Dr. Brian Cunningham at the University of Illinois. The focus of his research is the design and characterization of enhanced sensitivity photonic crystal biosensors. Leo Li-Ying Chan is a graduate research assistant at the University of Illinois at Urbana-Champaign in the Nano Sensors Group directed by Dr. Brian T. Cunningham. His research focuses on the characterization of photonic crystal optical biosensors and the optimization of small molecule biodetection using this platform. Before joining Dr. Cunningham's group, Leo Chan served as an undergraduate research at Keck Graduate Institute: Claremont, California, where he worked on the application of free solution electrophoresis to DNA finger printing. He earned his BS and MS in Electrical and Computer Engineering with a minor in Biomedical Engineering from the University of Illinois at Urbana-Champaign, where he is currently pursuing a PhD. Brian T. Cunningham (PhD) is an Associate Professor of Electrical and Computer Engineering at the University of Illinois at Urbana-Champaign, where he is the director of the Nano Sensors Group. His group focuses on the development of photonic crystal-based transducers, plastic-based fabrication methods, and novel instrumentation approaches for label-free biodetection. Prof. Cunningham is a founder and the Chief Technical Officer of SRU Biosystems (Woburn, MA), a life science tools company that provides high sensitivity plastic-based optical biosensors, instrumentation, and software to the pharmaceutical, academic research, genomics, and proteomics communities. Prior to founding SRU Biosystems in June, 2000, Dr. Cunningham was the Manager of Biomedical Technology at Draper Laboratory (Cambridge, MA), where he directed R&D projects aimed at utilizing defense-related technical capabilities for medical applications. In addition, Dr. Cunningham served as Group Leader for MEMS Sensors at Draper Laboratory, where he directed a group performing applied research on microfabricated inertial sensors, acoustic sensors, optical switches, microfluidics, tissue engineering, and biosensors. Concurrently, he was an Associate Director of the Center for Innovative Minimally Invasive Therapy (CIMIT), a Boston-area medical technology consortium, where he led the Advanced Technology Team on Microsensors. Before working at Draper Laboratory, Dr. Cunningham spent 5 years at the Raytheon Electronic Systems Division developing advanced infrared imaging array technology for defense and commercial applications. Dr. Cunningham earned his BS, MS, and PhD degrees in Electrical and Computer Engineering at the University of Illinois. His thesis research was in the field of optoelectronics and compound semiconductor material science, where he contributed to the development of crystal growth techniques that are now widely used for manufacturing solid state lasers, and high frequency amplifiers for wireless communication.
PY - 2005
Y1 - 2005
N2 - The sensitivity of a photonic crystal optical biosensor is greatly enhanced through the incorporation of low refractive index porous dielectric material into the device structure. In this work, computer models are used to predict the reflectance spectra and sensitivity performance of a one-dimensional photonic crystal biosensor. A manufacturable replication method is demonstrated that can produce a low-index dielectric periodic surface structure with a 550 nm period over large surface areas. The sensitivity of porous glass biosensors is characterized and compared with sensors incorporating non-porous polymer material. Results for detection of proteins, polymer layers, and bulk liquids indicate up to a four fold sensitivity increase.
AB - The sensitivity of a photonic crystal optical biosensor is greatly enhanced through the incorporation of low refractive index porous dielectric material into the device structure. In this work, computer models are used to predict the reflectance spectra and sensitivity performance of a one-dimensional photonic crystal biosensor. A manufacturable replication method is demonstrated that can produce a low-index dielectric periodic surface structure with a 550 nm period over large surface areas. The sensitivity of porous glass biosensors is characterized and compared with sensors incorporating non-porous polymer material. Results for detection of proteins, polymer layers, and bulk liquids indicate up to a four fold sensitivity increase.
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U2 - 10.1109/ICSENS.2005.1597806
DO - 10.1109/ICSENS.2005.1597806
M3 - Conference contribution
AN - SCOPUS:33847266841
SN - 0780390563
SN - 9780780390560
T3 - Proceedings of IEEE Sensors
SP - 742
EP - 745
BT - Proceedings of the Fourth IEEE Conference on Sensors 2005
T2 - Fourth IEEE Conference on Sensors 2005
Y2 - 31 October 2005 through 3 November 2005
ER -