Photonic Crystal Enhanced Fluorescence with DNA-based Nano-gripper for Ultrasensitive SARS-CoV-2 Biosensing

Yanyu Xiong, Lifeng Zhou, Laura Cooper, Skye Shepherd, Tingjie Song, Abhisek Dwivedy, Lijun Rong, Tong Wang, Xing Wang, Brian T. Cunningham

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

DNA-origami based nano-grippers, integrated with aptamer-based nanoswitches, generate fluorescent signals when detecting SARS-CoV-2. The integration of Photonic Crystal Enhanced Fluorescence Microscope enables a 104-fold enhancement compared to a single fluorophore reporter on glass substrate, providing a promising tool for ultrasensitive detection and rapid diagnostics.

Original languageEnglish (US)
Title of host publication2023 IEEE Photonics Conference, IPC 2023 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9798350347227
DOIs
StatePublished - 2023
Event2023 IEEE Photonics Conference, IPC 2023 - Orlando, United States
Duration: Nov 12 2023Nov 16 2023

Publication series

Name2023 IEEE Photonics Conference, IPC 2023 - Proceedings

Conference

Conference2023 IEEE Photonics Conference, IPC 2023
Country/TerritoryUnited States
CityOrlando
Period11/12/2311/16/23

Keywords

  • Biosensing
  • DNA-origami
  • Enhanced Fluorescence
  • Photonic Crystal

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Networks and Communications
  • Safety, Risk, Reliability and Quality
  • Control and Optimization
  • Atomic and Molecular Physics, and Optics

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