Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection

Anusha Pokhriyal, Meng Lu, Vikram Chaudhery, Cheng Sheng Huang, Stephen Schulz, Brian T. Cunningham

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A Photonic Crystal surface fabricated upon a quartz substrate using nanoimprint lithography has been demonstrated with a signal enhancement factor as high as 7500 for the detection of LD-700 dye spin-coated upon the PC. The detection of spotted Alexa-647 labeled polypeptide on the PC exhibits a 330 SNR improvement. Using dose-response characterization of deposited fluorophore-tagged protein spots, the PCEF surface demonstrated a 140 lower limit of detection compared to a conventional glass substrate.

Original languageEnglish (US)
Title of host publication2011 Conference on Lasers and Electro-Optics
Subtitle of host publicationLaser Science to Photonic Applications, CLEO 2011
StatePublished - 2011
Event2011 Conference on Lasers and Electro-Optics, CLEO 2011 - Baltimore, MD, United States
Duration: May 1 2011May 6 2011

Other

Other2011 Conference on Lasers and Electro-Optics, CLEO 2011
CountryUnited States
CityBaltimore, MD
Period5/1/115/6/11

Fingerprint

Quartz
Photonic crystals
quartz
Fluorescence
photonics
Nanoimprint lithography
fluorescence
Fluorophores
Polypeptides
Substrates
crystals
Coloring Agents
Dyes
polypeptides
Proteins
crystal surfaces
Glass
Peptides
lithography
dyes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Pokhriyal, A., Lu, M., Chaudhery, V., Huang, C. S., Schulz, S., & Cunningham, B. T. (2011). Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection. In 2011 Conference on Lasers and Electro-Optics: Laser Science to Photonic Applications, CLEO 2011 [5950506]

Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection. / Pokhriyal, Anusha; Lu, Meng; Chaudhery, Vikram; Huang, Cheng Sheng; Schulz, Stephen; Cunningham, Brian T.

2011 Conference on Lasers and Electro-Optics: Laser Science to Photonic Applications, CLEO 2011. 2011. 5950506.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pokhriyal, A, Lu, M, Chaudhery, V, Huang, CS, Schulz, S & Cunningham, BT 2011, Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection. in 2011 Conference on Lasers and Electro-Optics: Laser Science to Photonic Applications, CLEO 2011., 5950506, 2011 Conference on Lasers and Electro-Optics, CLEO 2011, Baltimore, MD, United States, 5/1/11.
Pokhriyal A, Lu M, Chaudhery V, Huang CS, Schulz S, Cunningham BT. Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection. In 2011 Conference on Lasers and Electro-Optics: Laser Science to Photonic Applications, CLEO 2011. 2011. 5950506
Pokhriyal, Anusha ; Lu, Meng ; Chaudhery, Vikram ; Huang, Cheng Sheng ; Schulz, Stephen ; Cunningham, Brian T. / Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection. 2011 Conference on Lasers and Electro-Optics: Laser Science to Photonic Applications, CLEO 2011. 2011.
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AU - Cunningham, Brian T.

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